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首页> 外文期刊>感染症学雑誌 >Comparison of four diagnostic methods using clinical blood by measuring (1-->3)-beta-D-glucan
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Comparison of four diagnostic methods using clinical blood by measuring (1-->3)-beta-D-glucan

机译：通过测量（1-> 3）-β-D-葡聚糖比较四种使用临床血液的诊断方法

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    Using Amebocyte lysate of horseshoe crab to measure (1-->3)-beta-D-glucan specifically, a component of the cell wall, several kinds of diagnostic methods for deep mycosis are in practical use in Japan. However, the most important problem is that the judgment of positive or negative is method dependent. To elucidate the cause of the problem, each measurement value of the identical sample by four methods, beta-Glucan Test Maruha (MARUHA), beta-Glucan Test Wako (WAKO). FUNGITEC G Test (FUNGITEC-G) and FUNGITEC G Test MK (FUNGITEC-MK) was compared with the clinical data using 119 cases and 289 tests. Each case was divided into three groups; proven fungal infection, probable fungal infection and non-fungal infection. The negative cases for all the methods tested in the groups of proven fungal infection and probable fungal infection were allergic bronchopulmonary aspergillosis and cryptococcosis, and that for all the methods tested except FUNGITEC-MK method in the group was pulmonary aspergilloma. It seems that these cases cannot be detected correctly by only measuring (1-->3)-beta-D-glucan. On the other hand, the ratio of false positive, positive for non-fungal infection group was high in the case of FUNGITEC-MK. About 23% against the total case was positive for FUNGITEC-MK method, but negative for MARUHA, WAKO, and FUNGITEC-G methods. Although the difference of the sensitivity among four methods was not observed, the specificity, the diagnostic efficiency, and the positive predictive value of FUNGITEC-MK method were remarkably lower than those of the other methods due to false positive measurement. In conclusion, MARUHA, WAKO and FUNGITEC-G except FUNGITEC-MK is not method dependent. It is suggested that FUNGITEC-MK detects non-specific reaction resulted in false positive.
    机译：在日本，利用of的Amebocyte裂解物专门测量（1-> 3）-β-D-葡聚糖，它是细胞壁的组成部分，有几种用于深部真菌病的诊断方法。但是，最重要的问题是，对肯定或否定的判断取决于方法。为了阐明问题的原因，使用四种方法，β-葡聚糖测试丸（MARUHA），β-葡聚糖测试和光（WAKO），对相同样品的每个测量值进行测量。将FUNGITEC G检验（FUNGITEC-G）和FUNGITEC G检验（FUNGITEC-MK）与119例和289例检验的临床数据进行了比较。每个病例分为三组。经证实的真菌感染，可能的真菌感染和非真菌感染。在已证实的真菌感染和可能的真菌感染组中，所有测试方法的阴性病例均为过敏性支气管肺曲菌病和隐球菌病，除FUNGITEC-MK方法外，所有测试方法均为肺曲霉菌。似乎仅通过测量（1-> 3）-β-D-葡聚糖无法正确检测到这些情况。另一方面，在FUNGITEC-MK的情况下，非真菌感染组的假阳性，阳性比率很高。相对于总病例，约23％的FUNGITEC-MK方法为阳性，而MARUHA，WAKO和FUNGITEC-G方法为阴性。尽管未观察到四种方法之间的灵敏度差异，但由于假阳性检测，FUNGITEC-MK方法的特异性，诊断效率和阳性预测值明显低于其他方法。总之，除了FUNGITEC-MK之外，MARUHA，WAKO和FUNGITEC-G不依赖于方法。建议FUNGITEC-MK检测到导致假阳性的非特异性反应。

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