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首页> 外文期刊>感染症学雑誌 >Drug sensitivity and teicoplanin resistance of coagulase-negative Staphylococcus isolated from blood culture
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Drug sensitivity and teicoplanin resistance of coagulase-negative Staphylococcus isolated from blood culture

机译：血液培养中凝固酶阴性葡萄球菌的药敏性和替考拉宁耐药性

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摘要

Drug sensitivity and teicoplanin (TEIC) resistance of coagulase-negative Staphylococcus spp (CNS) isolated from blood culture in 10 years between 1992 and 2001 were investigated, and epidemiological analysis was performed using the survey of clinical backgrounds. Regarding the resistance rates of CNS to various drugs, no isolate was resistant to vancomycin (VCM), arbekacin (ABK), and linezolid (LZD), but the minimum inhibitory concentration (MIC) of TEIC was 16 micrograms/ml or higher in 10.3% of isolates. The isolates include 56 S. epidermidis strains, 1 S. capitis strain and 4 S. haemolyticus strains. As for other drugs, the minocycline (MINO) resistance rate was relatively low (6.1%), and methicillin-resistant CNS (MRCNS) accounted for 67.1%. The resistance rate was high for many drugs between 1995 and 1997. MIC50/90 of drugs considered to be anti-Staphylococcus were 1/2 microgram/ml (VCM), 1/16 microgram/ml (TEIC), 0.25/1 microgram/ml (ABK) and 1/2 microgram/ml (LZD), showing that both MIC 50 and MIC90 of ABK were the lowest. Regarding cross-resistance to TEIC, the resistant group (MIC: 16 micrograms/ml or higher) exhibited cross-resistance to all drugs excluding MINO. Particularly, 90.2% of the TEIC resistant group was MRCNS. TEIC-resistant strain was most frequently (30.8%) detected in the pediatric ward. In comparison of clinical backgrounds of the TEIC-resistant and TEIC-sensitive groups, there were no significant differences in age, use of IVH, or prognosis, but a significant difference in detection of TEIC-resistant strains was noted in patients treated with the 4 th cepharosporins and carbapenems (p < 0.01). This survey clarified the presence of TEIC-resistant CNS strains. We will continue the survey to monitor resistance conversion. Investigation of the involvement of TEIC-resistant CNS strains in hospital infection and therapeutic course is also necessary.
机译：对1992年至2001年10年间从血培养中分离出的凝固酶阴性葡萄球菌spp（CNS）的药敏性和替考拉宁（TEIC）耐药性进行了调查，并根据临床背景进行了流行病学分析。关于中枢神经系统对多种药物的耐药率，没有分离株对万古霉素（VCM），阿贝卡星（ABK）和利奈唑胺（LZD）耐药，但TEIC的最低抑菌浓度（MIC）在16.3中为16微克/ ml或更高。分离株百分比。分离株包括表皮葡萄球菌56株，头孢葡萄球菌1株和溶血链球菌4株。至于其他药物，其对米诺环素（MINO）的耐药率相对较低（6.1％），对耐甲氧西林的CNS（MRCNS）占67.1％。在1995年至1997年之间，许多药物的耐药率很高。被认为是抗葡萄球菌的药物的MIC50 / 90为1/2微克/毫升（VCM），1/16微克/毫升（TEIC），0.25 / 1微克/毫升（ABK）和1/2微克/毫升（LZD），表明ABK的MIC 50和MIC90最低。关于对TEIC的交叉耐药性，耐药组（MIC：16微克/毫升或更高）对除MINO以外的所有药物均表现出交叉耐药性。特别地，90.2％的TEIC抗性组是MRNCS。在儿科病房中，最常检测到TEIC耐药株（30.8％）。比较TEIC耐药组和TEIC敏感组的临床背景，年龄，IVH的使用或预后没有显着差异，但是用4种药物治疗的患者在TEIC耐药菌株的检测上存在显着差异。头孢菌素和碳青霉烯类（p <0.01）。这项调查澄清了耐TEIC的CNS菌株的存在。我们将继续调查以监测电阻转换。还需要研究耐TEIC的中枢神经系统菌株在医院感染和治疗过程中的参与。

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