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首页> 外文期刊>Comparative biochemistry and physiology, Part C. Pharmacology, toxicology and endocrinology: An international journal >Inhibition of complement activation by water-soluble polysaccharides of some far-eastern brown seaweeds
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Inhibition of complement activation by water-soluble polysaccharides of some far-eastern brown seaweeds

机译：水溶性多糖对某些远东褐海藻的抑制作用

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Fucoidans and laminarans from Laminaria cichorioides, Laminaria japonica, Fucus evanescens, laminaran from Laminaria gurjanovae, other beta-D-glucans (translam, pustulan and zymosan) and lambda-carrageenan from Chondrus armatus were used to study the effect of water-soluble polysaccharides from seaweeds on the alternative pathway of complement (APC). beta-D-Glucans and fucoidans under study differed appreciably from each other by structural characteristics, and also by degree of purification. beta-D-glucans, on ability to bind complement, ranked in a line according to a degree of their purification. Highly purified P-D-glucans under study did not reveal an ability to bind complement. The fucoidans were divided conventionally into three groups according to their action on APC. Highly sulfated alpha-L-fucan from L. cichorioides with the greatest activity toward APC and caused 50% inhibition of reaction of activation (RA) of APC in a concentration of 0.5-0.7 mg/ml. Opposite 50% of inhibition of lysis of erythrocytes by sulfated heterogeneous fucoidan from L.japonica was achieved with 20 mg/ml. All other fucoidans and lambda-carrageenan have activity at 6-10 mg:ml concentration. Decreasing the sulfate content from 36% up to 9% in sample fucoidans under study was not reflected practically in the 50% inhibition concentration. Apparently, the degree of sulfating of fucoidans did not influence their action on APC. But the positive influence of fucose in structure of polysaccharide was obvious. (C) 2000 Elsevier Science Inc. All rights reserved. [References: 25]
机译：用来自海带的海藻，日本海带，长叶海藻，来自海带的海藻，其他β-D-葡聚糖（translam，pustulan和zymosan）和得自香荚鱼的软骨的λ-角叉菜胶来研究多糖的水溶性。海藻的补体替代途径（APC）。所研究的β-D-葡聚糖和岩藻依聚糖在结构特征和纯化程度上均存在明显差异。 β-D-葡聚糖结合补体的能力根据其纯化程度排列在一条直线上。研究中的高纯度β-D-葡聚糖未显示出结合补体的能力。根据岩藻依聚糖对APC的作用，按常规将其分为三类。柠檬酸乳杆菌中高度硫酸化的α-L-富康对APC具有最大活性，在0.5-0.7 mg / ml的浓度下可引起50％抑制APC活化反应（RA）。以20 mg / ml的浓度对来自日本狼尾草的硫酸化异种岩藻依聚糖的抑制作用相对于红细胞的50％。所有其他岩藻依聚糖和λ-角叉菜聚糖在6-10 mg：ml的浓度下均具有活性。在所研究的岩藻依聚糖中，硫酸盐含量从36％降低至9％几乎没有反映在50％抑制浓度下。显然，岩藻依聚糖的硫酸化程度并不影响其对APC的作用。但是岩藻糖对多糖结构的积极影响是显而易见的。 （C）2000 Elsevier Science Inc.保留所有权利。 [参考：25]

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