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首页> 外文期刊>Comparative biochemistry and physiology, Part C. Pharmacology, toxicology and endocrinology: An international journal >Metabolism of benzo(a)pyrene by duck liver microsomes
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Metabolism of benzo(a)pyrene by duck liver microsomes

机译：鸭肝微粒体代谢苯并（a）py

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The metabolism of benzo(a)pyrene [BP], a model carcinogenic PAH, by hepatic microsomes of two duck species, mallard (Anas platyrhynchos) and common merganser (Mergus merganser americanus) collected from chemically-contaminated and relatively non-contaminated areas was investigated. The rate of metabolism of BP by liver microsomes of common merganser and mallard collected from polluted areas (2650 +/- 310 and 2200 +/- 310 pmol/min per mg microsomal protein, respectively) was significantly higher than that obtained with liver microsomes of the two species collected from non-polluted areas (334 +/- 33 and 231 +/- 30 pmol/min per mg microsomal protein. respectively). The level of cytochrome P450 1A1 was significantly higher in the liver microsomes of both duck species from the polluted areas as compared to the ducks from the non-polluted areas. The major BP metabolites, including BP-9, 10-diol, BP-4, 5-diol, BP-7, 8-diol, BP-1, 6-dione, BP-3, 6-dione, BP-6, 12-dione, 9-hydroxy-BP and 3-hydroxy-BP, formed by liver microsomes of both duck species from polluted and non-polluted areas, were qualitatively similar. However, the patterns of these metabolites were considerably different from each other. Liver microsomes of ducks from the polluted areas produced a higher proportion of benzo-ring dihydrodiols than the liver microsomes of ducks from the non-polluted areas, which converted a greater proportion of BP to BP-phenols. The predominant enantiomer of BP-7,8-diol formed by hepatic microsomes of the two duck species had an (-)R,R absolute stereochemistry. The data suggest that duck and rat liver microsomal enzymes have different regioselectivity but similar stereoselectivity in the metabolism of BP. (C) 2000 Elsevier Science Inc. All rights reserved. [References: 26]
机译：从化学污染和相对未污染的地区收集的两种鸭物种（野鸭（Anas platyrhynchos）和普通秋沙鸭（Mergus merganser americanus））的肝微粒体对苯并（a）py [BP]（一种致癌的PAH）进行了代谢。调查。从污染区域收集的普通秋沙鸭和绿头鸭肝微粒体对BP的代谢速率（分别为每毫克微粒体蛋白2650 +/- 310和2200 +/- 310 pmol / min）显着高于使用从无污染区域收集的两个物种（分别为每毫克微粒体蛋白334 +/- 33 pmol / min和231 +/- 30 pmol / min）。与来自未污染地区的鸭子相比，来自受污染地区的两种鸭子物种的肝微粒体中细胞色素P450 1A1的水平均显着更高。 BP的主要代谢产物，包括BP-9、10-二醇，BP-4、5-二醇，BP-7、8-二醇，BP-1、6-二酮，BP-3、6-二酮，BP-6，由污染和非污染地区的鸭种肝脏微粒体形成的12-二酮，9-羟基-BP和3-羟基-BP在质量上相似。但是，这些代谢物的模式彼此之间存在很大差异。来自受污染地区的鸭肝微粒体产生的苯并环二氢二醇比例要高于来自无污染地区的鸭肝微粒体，后者将更大比例的BP转化为BP-酚。由两种鸭种的肝微粒体形成的BP-7,8-二醇的主要对映体具有（-）R，R绝对立体化学。数据表明，鸭和大鼠肝脏微粒体酶在BP代谢中具有不同的区域选择性，但具有相似的立体选择性。 （C）2000 Elsevier Science Inc.保留所有权利。 [参考：26]

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