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首页> 外文期刊>Comparative biochemistry and physiology, Part C. Pharmacology, toxicology and endocrinology: An international journal >Differences in mGnRH and cGnRH-II contents in pituitaries and discrete brain areas of Rana rugulosa W. according to age and stage of maturity
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Differences in mGnRH and cGnRH-II contents in pituitaries and discrete brain areas of Rana rugulosa W. according to age and stage of maturity

机译：根据年龄和成熟阶段，ana蛙垂体和离散脑区的mGnRH和cGnRH-II含量的差异

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(1) In tadpoles, chicken-II gonadotropin-releasing hormone (cGnRH-I1) could be measured in the brains before metamorphosis, but mammalian gonadotropin-releasing hormone (mGnRH) did not appear until the stage of metamorphosis, i.e. cGnRH-II appeared earlier than mGnRH during ontogenesis. (2) During the metamorphic climax, mGnRH content increased more rapidly than cGnRH-II; the content of mGnRH was about two times of that of cGnRH-II. (3) In juveniles and adults, the content of mGnRH and cGnRH-II, and the distribution pattern of mGnRH (but not cGnRH-II) in the brains and pituitaries changed with age and stages of gonadal development, mGnRH mainly distributed in the rostral brain areas, whereas cGnRH-II had a widespread distribution in the brain. (4) Both mGnRH and cGnRH-II were present in the pituitaries at each stage of maturity. The gonadotropin-releasing hormone (GnRH) content at sexually maturity was significantly higher than that at other stages of gonadal development, and the content of mGnRH was about 15-18 times of that of cGnRH-II. (5) These results suggest that both mGnRH and cGnRH-II are potentially involved in the direct regulation of pituitary gonadotropes, and mGnRH may be the major active form, cGnRH-II may also serve as a neurotransmitter or neuromodulator in the brain. (C) 2000 Elsevier Science Inc. All rights reserved. [References: 38]
机译：（1）在t中，可以在变态前在大脑中测量鸡II型促性腺激素释放激素（cGnRH-I1），但直到变态阶段才出现哺乳动物促性腺激素释放激素（mGnRH），即出现cGnRH-II。在致癌过程中比mGnRH更早。 （2）在变质高潮期间，mGnRH含量的增加速度快于cGnRH-II; mGnRH的含量约为cGnRH-II的两倍。 （3）在少年和成年人中，mGnRH和cGnRH-II的含量以及mGnRH（但不是cGnRH-II）在脑和垂体中的分布模式随性腺发育的年龄和阶段而变化，mGnRH主要分布在嘴侧大脑区域，而cGnRH-II在大脑中分布广泛。 （4）在成熟的每个阶段，垂体中都存在mGnRH和cGnRH-II。性成熟时促性腺激素释放激素（GnRH）的含量显着高于性腺发育其他阶段的水平，而mGnRH的含量约为cGnRH-II的15-18倍。 （5）这些结果表明，mGnRH和cGnRH-II都可能参与垂体促性腺激素的直接调节，而mGnRH可能是主要的活性形式，cGnRH-II也可以充当大脑中的神经递质或神经调节剂。 （C）2000 Elsevier Science Inc.保留所有权利。 [参考：38]

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