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首页> 外文期刊>臨床病理 >Urinary 17-hydroxycorticosteroids and 17-ketosteroid sulfates in normal children and in children with atopic dermatitis or renal disease.
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Urinary 17-hydroxycorticosteroids and 17-ketosteroid sulfates in normal children and in children with atopic dermatitis or renal disease.

机译：正常儿童和特应性皮炎或肾病儿童的尿中17-羟基皮质类固醇和17-酮类固醇硫酸盐。

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摘要

We measured both urinary 17-hydroxycorticosteroids(17-OHCS) and 17-ketosteroid sulfates(17-KS-S) in normal children and in children with some diseases to evaluate adaptation to stress in children. 17-OHCS and 17-KS-S values were measured in morning urine from 60 normal children(3-18 years old) and 24 children with atopic dermatitis or renal disease. In normal children, the 17-OHCS/creatinine showed no difference by age, but both 17-KS-S/creatinine and 17-KS-S/17-OHCS showed significant positive correlation with age. No sex differences were significant. In children with atopic dermatitis or with renal disease treated with cyclosporine A, 17-OHCS/creatinine was significantly higher and the 17-KS-S/17-OHCS ratio was significantly lower than in age-matched controls. These values returned to normal as the conditions improved or as treatment ended. In patients who underwent renal biopsy, both 17-OHCS/creatinine and 17-KS-S/creatinine values were significantly higher after biopsy than before because of the stress caused by pain and complete bed rest. Measurement of urinary 17-OHCS and 17-KS-S in children can be useful for evaluation of adaptation to stress as well as in adults.
机译：我们测量了正常儿童和患有某些疾病的儿童中的尿液中的17-羟基皮质类固醇（17-OHCS）和17-酮类固醇硫酸盐（17-KS-S），以评估儿童对压力的适应性。在60名正常儿童（3-18岁）和24名患有特应性皮炎或肾脏疾病的儿童的早晨尿液中测量了17-OHCS和17-KS-S值。在正常儿童中，17-OHCS /肌酐在年龄上没有差异，但是17-KS-S /肌酐和17-KS-S / 17-OHCS与年龄呈显着正相关。没有性别差异显着。在患有特应性皮炎或肾脏疾病的儿童中，用环孢霉素A治疗的儿童的17-OHCS /肌酐明显高于年龄匹配的对照组，而17-KS-S / 17-OHCS的比例则明显较低。随着病情改善或治疗结束，这些值恢复正常。在接受肾活检的患者中，由于疼痛和完全卧床引起的压力，活检后17-OHCS /肌酐和17-KS-S /肌酐值均显着高于以前。儿童尿液中17-OHCS和17-KS-S的测定可用于评估对压力的适应性以及对成年人的适应性。

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