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Prognosis of chronic hepatitis C with regard to the aim of treatment

机译：就治疗目的而言，慢性丙型肝炎的预后

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Epidemiology of hepatitis C virus(HCV) infection and clinical prognosis of chronic hepatitis C were presented here to reveal the object of treatment of Chronic Hepatitis C. Hepatitis C Virus is transmitted by blood and blood products. After acute HCV infection, about 70% developed persistent HCV infection, and the diagnosis is by finding viral RNA in the serum of patients with anti-HCV antibody. Persistent HCV infection causes chronic hepatitis, in which the natural clearance of HCV is almost impossible and there is almost no natural cure for chronic hepatitis caused by HCV. Chronic hepatitis C tends to develop gradually and to progress to liver cirrhosis, and is involved in the pathogenesis of hepatocellular carcinoma. In Japanese patients with chronic hepatitis C, 45% developed liver cirrhosis pass through a phase of chronic active hepatitis over a 15-year course after initial HCV infection, and 25% developed hepatocellular carcinoma over a 20-year course after the initial HCV infection. In addition the remaining patients may start to develop rapidly to chronic active hepatitis and to liver cirrhosis after 20 to 30 years duration of inactive phase. Thus, this type of chronic hepatitis reveals a poor long-term prognosis. For etiological treatment of chronic hepatitis C, eradication of persistent HCV infection is needed. If this is impossible, then preventing the development of liver cirrhosis and hepatocellular carcinoma is important.
机译：本文介绍了丙型肝炎病毒（HCV）感染的流行病学和慢性丙型肝炎的临床预后，以揭示治疗慢性丙型肝炎的目的。丙型肝炎病毒通过血液和血液制品传播。急性HCV感染后，约70％的人发展为持续性HCV感染，诊断是通过在抗HCV抗体患者的血清中发现病毒RNA。持续的HCV感染会导致慢性肝炎，其中HCV的自然清除几乎是不可能的，并且几乎没有自然疗法可治愈HCV引起的慢性肝炎。慢性丙型肝炎倾向于逐渐发展并发展为肝硬化，并参与肝细胞癌的发病机制。在日本患有慢性丙型肝炎的患者中，最初的HCV感染后15年内，有45％的患者发展为肝硬化，并经历了慢性活动性肝炎;在最初的HCV感染后的20年内，有25％的患者发展为肝细胞癌。此外，其余患者可能会在非活动期持续20至30年后开始迅速发展为慢性活动性肝炎和肝硬化。因此，这种类型的慢性肝炎显示不良的长期预后。对于慢性丙型肝炎的病因治疗，需要消除持续的HCV感染。如果这不可能，那么预防肝硬化和肝细胞癌的发展就很重要。

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