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首页> 外文期刊>藥學雜誌 >Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models.
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Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models.

机译：龙葵氯仿提取物在动物模型中的抗伤害，消炎和解热作用。

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AIM: The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of chloroform extract of Solanum nigrum leaves using various animal models. METHODS: The extract was prepared by soaking (1:20; w/v) the air-dried powdered leaves (20 g) in chloroform for 72 hrs followed by evaporation (40 degrees C) under reduced pressure to dryness (1.26 g) and then dissolved (1:50; w/v) in dimethylsulfoxide (DMSO). The supernatant, considered as the stock solution with dose of 200 mg/kg, was diluted using DMSO to 20 and 100 mg/kg, and all doses were administered (s.c.; 10 ml/kg) in mice/rats 30 min prior to tests. RESULTS: The extract exhibited significant (p<0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (p<0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests. Overall, the activities occurred in a dose-independent manner. CONCLUSION: The present study demonstrated that the lipid-soluble extract of S. nigrum leaves possessed antinociceptive, anti-inflammatory and anti-pyretic properties and confirmed the traditional claims.
机译：目的：本研究是使用多种动物模型评估龙葵叶中氯仿提取物的​​镇痛，抗炎和解热作用的。方法：提取物的制备方法是：将风干的粉状叶子（20 g）在氯仿中浸泡（1:20; w / v）72小时，然后在减压下蒸发（40°C）干燥至干燥（1.26 g），然后溶解（1：50; w / v）在二甲基亚砜（DMSO）中。使用DMSO将上清液（视为200 mg / kg的储备液）稀释至20和100 mg / kg，并在测试前30分钟在小鼠/大鼠中施用所有剂量（sc; 10 ml / kg） 。结果：使用腹部收缩，热板和福尔马林测试评估提取物具有显着（p <0.05）的抗伤害感受活性。当使用角叉菜胶诱导的爪水肿和啤酒酵母引起的发热试验进行评估时，提取物还具有显着的抗炎和解热活性（p <0.05）。总体而言，这些活动以剂量无关的方式发生。结论：本研究表明，黑芥的脂溶性提取物具有抗伤害，消炎和退热的特性，并证实了传统的说法。

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