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首页> 外文期刊>Biopreservation and biobanking >Generating a Comprehensive Set of Standard Operating Procedures for a Biorepository Network—The CTRNet Experience
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Generating a Comprehensive Set of Standard Operating Procedures for a Biorepository Network—The CTRNet Experience

机译：为生物存储网络生成一套全面的标准操作程序— CTRNet经验

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Despite the integral role of biorepositories in fueling translational research and the advancement of medicine, there are significant gaps in harmonization of biobanking practices, resulting in variable biospecimen collection, storage, and processing. This significantly impacts accurate downstream analysis and, in particular, creates a problem for biorepository networks or consortia. The Canadian Tumour Repository Network (CTRNet; www.ctrnet.ca) is a consortium of Canadian tumor biorepositories that aims to enhance biobanking capacity and quality through standardization. To minimize the issue of variable biobanking practices throughout its network, CTRNet has developed and maintained a comprehensive set of 45 standard operating procedures (SOPs). There were four key elements to the CTRNet SOP development process: 1) an SOP development team was formed from members across CTRNet to co-produce each SOP; 2) a principal author was appointed with responsibility for overall coordination of the SOP development process; 3) the CTRNet Management Committee (composed of principal investigators for each member biorepository) reviewed/revised each SOP completed by the development team; and 4) external expert reviewers provided feedback and recommendations on each SOP. Once final Management Committee approval was obtained, the ratified SOP was published on the CTRNet website for public access. Since the SOPs were first published on the CTRNet website (June 2008), there have been approximately 15,000 downloads of one or more CTRNet SOPs/Policies by users from over 60 countries. In accordance with biobanking best practices, CTRNet performs an exhaustive review of its SOPs at set intervals, to coincide with each granting cycle. The last revision was completed in May 2012.
机译：尽管生物存储库在推动转化研究和医学发展方面起着不可或缺的作用，但在统一生物库实践方面仍存在巨大差距，导致生物标本的收集，存储和加工过程各不相同。这极大地影响了准确的下游分析，特别是对生物存储网络或财团造成了问题。加拿大肿瘤储存库网络（CTRNet; www.ctrnet.ca）是加拿大肿瘤生物储存库的联盟，旨在通过标准化来增强生物储存能力和质量。为了最大程度地减少整个网络中可变的生物银行做法的问题，CTRNet已开发并维护了一套完整的45套标准操作程序（SOP）。 CTRNet SOP开发流程有四个关键要素：1）由CTRNet的成员组成一个SOP开发团队，以共同制作每个SOP; 2）任命了一位主要作者，负责SOP开发流程的总体协调; 3）CTRNet管理委员会（由每个成员生物存储库的主要研究人员组成）审查/修订了开发团队完成的每个SOP; 4）外部专家评审员就每个SOP提供了反馈和建议。一旦获得管理委员会的最终批准，批准的SOP将发布在CTRNet网站上以供公众访问。自从SOP首次在CTRNet网站上发布（2008年6月）以来，已有来自60多个国家的用户下载了15,000份CTRNet SOP /政策。根据生物库最佳实践，CTRNet会按设定的时间间隔对其SOP进行详尽的审查，以与每个授予周期一致。上一次修订于2012年5月完成。

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