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首页> 外文期刊>臨床血液 >Effectiveness of oral vitamin B12 therapy for pernicious anemia and vitamin B12 deficiency anemia
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Effectiveness of oral vitamin B12 therapy for pernicious anemia and vitamin B12 deficiency anemia

机译：口服维生素B12治疗恶性贫血和维生素B12缺乏性贫血的有效性

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We investigated the efficacy of oral vitamin B12 (B12) therapy in patients with B12-deficiency anemia. Between June 1994 and June 2000, 17 patients, who were diagnosed as having B12-deficiency anemia and gave their informed consent, were enrolled in this study. Of these patients, 7 were further treated with a maintenance dose of methylcobalamin (1,500 micrograms daily for 7 days every 1-3 months). Correction of hematological and neurological abnormalities was prompt. The hemoglobin level and serum concentration of B12 were normalized within two months after starting the treatment. Recovery from neurological disturbance was observed within one month. To maintain a normal serum concentration of B12, a 7-day regime of administration was needed every month in 3 patients, every 2 months in 3 patients, and every 3 months in 1 patient. These results demonstrate the effectiveness of oral cobalamin therapy, and also that oral intermittent therapy is useful for maintaining a normal serum B12 concentration. Oral cobalamin therapy might be as effective as conventional injection therapy, and useful for long-term treatment.
机译：我们调查了口服维生素B12（B12）治疗对B12缺乏性贫血患者的疗效。在1994年6月至2000年6月之间，共有17名被诊断患有B12缺乏性贫血并获得知情同意的患者参加了本研究。在这些患者中，有7位患者接受了维持剂量的甲基钴胺素治疗（每1-3个月每天1,500微克，共7天）。及时纠正血液和神经系统异常。在开始治疗后的两个月内，血红蛋白水平和血清B12浓度恢复正常。在一个月内观察到神经系统疾病的恢复。为了维持正常的血清B12浓度，3位患者每月需要7天的给药方案，3位患者每2个月一次，1位患者每3个月一次。这些结果证明了口服钴胺素疗法的有效性，并且口服间歇疗法对于维持正常的血清B12浓度是有用的。口服钴胺素疗法可能与常规注射疗法一样有效，并且可用于长期治疗。

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