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首页> 外文期刊>Comparative Medicine >Polyostotic fibrous dysplasia in a cynomolgus macaque (Macaca fascicularis).
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Polyostotic fibrous dysplasia in a cynomolgus macaque (Macaca fascicularis).

机译：食蟹猕猴（ Macaca fascicularis ）的多骨纤维化异常增生。

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A 2.3-y-old female cynomolgus macaque (Macaca fascicularis) presented with a broken right tibia and fibula. Radiographs showed multiple cyst-like defects in all long bones. We suspected that both fractures were pathologic because they occurred through these defects. Ultrasonography, MRI, and dual X-ray absorptiometry revealed that the defects were filled with soft tissue. Grossly, the bones were abnormal in shape, and a gelatinous material filled the defects and the surrounding marrow cavity. Histologically, the gelatinous material was composed of fibrin and cartilage; few normal bone cells were seen. Genetic testing revealed extra material on the short arm of chromosome 8 in all tissues examined, but no copy number alterations of likely clinical significance were observed, and no abnormalities were found that were unique to the lesions. In light of the clinical signs and radiographic and pathologic findings, polyostotic fibrous dysplasia was diagnosed. This report represents the first documented case of fibrous dysplasia in a cynomolgus macaque.
机译：一位2.3岁的雌性食蟹猕猴（ Macaca fascicularis ）的右胫骨和腓骨断裂。放射线照片显示在所有长骨中都有多个囊肿样缺损。我们怀疑这两个骨折都是病理性的，因为它们都是通过这些缺陷发生的。超声检查，MRI和双X线骨密度仪显示缺陷充满了软组织。总体而言，骨头的形状异常，并且凝胶状材料填充了缺损和周围的骨髓腔。在组织学上，凝胶状物质由纤维蛋白和软骨组成。几乎没有看到正常的骨细胞。基因检测显示，在所有检查的组织中，第8号染色体短臂上都有多余的物质，但未观察到可能具有临床意义的拷贝数变化，也未发现病变独特的异常。根据临床体征以及影像学和病理学发现，诊断为多发性纤维变性。该报告是食蟹猕猴中纤维性增生的首例记录病例。

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