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首页> 外文期刊>Comparative Medicine >Fecal Corticosterone Levels in RCAN1 Mutant Mice
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Fecal Corticosterone Levels in RCAN1 Mutant Mice

机译：RCAN1突变小鼠的粪便皮质酮水平

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摘要

Regulator of calcineurin 1 (RCAN1) is related to the expression of human neurologic disorders such as Down syndrome, Alzheimer disease, and chromosome 21q deletion syndrome. We showed here that RCAN1-knockout mice exhibit reduced innate anxiety as indicated by the elevated-plus maze. To examine whether glucocorticoids contribute to this phenotype, we measured fecal corticosterone in male wildtype and RCAN1-knockout mice and in male and female transgenic mice with neuronal overexpression of RCAN1 (Tg-RCAN1(TG)). We found no difference in fecal corticosterone levels of RCAN1-knockout mice and their wildtype littermates. As expected, we found differences between sexes in fecal corticosterone levels. In addition, we found higher levels of excreted corticosterone in Tg-RCAN1(TG) female mice as compared with female wildtype mice. Our data indicate normal diurnal corticosterone production in RCAN1 mutant mice and do not suggest a causal role in either the cognitive or anxiety phenotypes exhibited by RCAN1-knockout mice.
机译：钙调神经磷酸酶1（RCAN1）的调节剂与人类神经系统疾病，如唐氏综合症，阿尔茨海默氏病和21q染色体缺失综合症的表达有关。我们在这里显示，RCAN1基因敲除小鼠表现出先天性焦虑降低，如高架迷宫所示。若要检查糖皮质激素是否有助于此表型，我们测量了雄性野生型和RCAN1基因敲除小鼠以及神经元过度表达RCAN1（Tg-RCAN1（TG））的雄性和雌性转基因小鼠中的粪便皮质酮。我们发现RCAN1基因敲除小鼠及其野生型同窝仔的粪便皮质酮水平没有差异。不出所料，我们发现粪便皮质酮水平存在性别差异。此外，我们发现与雌性野生型小鼠相比，Tg-RCAN1（TG）雌性小鼠中分泌的皮质酮水平更高。我们的数据表明在RCAN1突变小鼠中正常的昼夜皮质酮生产，并不表明在RCAN1基因敲除小鼠表现出的认知或焦虑表型中有因果作用。

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