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首页> 外文期刊>Comparative Medicine >Comparison of Isoflurane and alpha-Chloralose in an Anesthetized Swine Model of Acute Pulmonary Embolism Producing Right Ventricular Dysfunction
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Comparison of Isoflurane and alpha-Chloralose in an Anesthetized Swine Model of Acute Pulmonary Embolism Producing Right Ventricular Dysfunction

机译：异戊烷和α-氯藻糖在麻醉性急性肺栓塞猪模型中引起右心室功能障碍的比较

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摘要

Pulmonary embolism (PE) is a leading cause of sudden cardiac death, and a model is needed for testing potential treatments. In developing a model, we compared the hemodynamic effects of isoflurane and alpha-chloralose in an acute swine model of PE because the choice of anesthesia will likely affect the cardiovascular responses of an animal to PE. At baseline, swine that received alpha-chloralose (n = 6) had a lower heart rate and cardiac output and higher SpOz end-tidal CO2 and mean arterial pressure than did those given isoflurane (n = 9). After PE induction, swine given alpha-chloralose compared with isoflurane exhibited a lower heart rate (63 +/- 10 compared with 116 15 bpm) and peripheral arterial pressure (52 +/- 12 compared with 61 +/- 12 mm Hg); higher SpO(2) (98% +/- 3% compared with 95% +/- 1%), end-tidal CO2 (35 +/- 4 compared with 32 +/- 5), and systolic blood pressure (121 +/- 8 compared with 104 +/- 20 mm Hg); and equivalent right ventricular:left ventricular ratios (1.32 +/- 0.50 compared with 1.23 +/- 0.19) and troponin I mean values (0.09 +/- 0.07 ng/mL compared with 0.09 +/- 0.06 ng/mL). Isoflurane was associated with widely variable fibrinogen and activated partial thromboplastin time. Intraexperiment mortality was 0 of 6 animals for alpha-chloralose and 2 of 9 swine for isoflurane. All swine anesthetized with alpha-chloralose survived with sustained pulmonary hypertension, RV-dilation-associated cardiac injury without the confounding vasodilatoiy or coagulatory effects of isoflurane. These data demonstrate the physiologic advantages of alpha-chloralose over isoflurane for anesthesia in a swine model of severe submassive PE.
机译：肺栓塞（PE）是导致心脏猝死的主要原因，因此需要一种模型来测试潜在的治疗方法。在建立模型时，我们比较了异氟烷和α-氯藻糖在PE急性猪模型中的血液动力学效应，因为麻醉的选择可能会影响动物对PE的心血管反应。在基线时，接受α-氯藻糖（n = 6）的猪比异氟烷（n = 9）具有更低的心率和心输出量，以及更高的SpOz潮气末二氧化碳和平均动脉压。诱导PE后，与异氟烷相比，给予α-氯草胺的猪表现出较低的心率（63 +/- 10与116 15 bpm相比）和外周动脉压（52 +/- 12与61 +/- 12 mm Hg相比）; SpO（2）更高（98％+/- 3％，而95％+/- 1％），潮气末CO2（35 +/- 4，而32 +/- 5）和收缩压（121 + /-8则为104 +/- 20毫米汞柱）;以及等效的右心室：左心室比率（1.32 +/- 0.50，而1.23 +/- 0.19）和肌钙蛋白I平均值（0.09 +/- 0.07 ng / mL，而0.09 +/- 0.06 ng / mL）。异氟烷与广泛变化的纤维蛋白原和部分凝血活酶激活时间有关。实验中死亡率为6只动物中的0只（对于α-氯藻糖）和9只猪中的2只（对于异氟烷）。所有用α-氯草胺麻醉的猪均在持续的肺动脉高压，RV扩张相关的心脏损伤中存活，而没有异氟烷的混杂血管扩张或凝血作用。这些数据证明了在重度亚大规模PE猪模型中，α-氯醛糖在麻醉中优于异氟烷的生理优势。

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