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首页> 外文期刊>Comparative Medicine >Postoperative analgesics in South African clawed frogs (Xenopus laevis) after surgical harvest of oocytes
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Postoperative analgesics in South African clawed frogs (Xenopus laevis) after surgical harvest of oocytes

机译：手术收获卵母细胞后南非爪蛙（Xenopus laevis）的术后镇痛药

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Heightened awareness for the welfare of earlier-evolved laboratory species has prompted increasing inquiries by institutional animal care committees, investigators, and laboratory animal veterinarians regarding the need for post-surgical analgesicsin laboratory Xenopus. Basic research into the mechanisms and regulation of pain in Rana pipiens has demonstrated the clinical potential of opioid, alpha_2-adrenergic, and non-opioid analgesic agents in amphibians. However, clinical studies using objectively established indices of amphibian pain, or pharmacological studies in either Rana pipiens or laboratory Xenopus have not been conducted. As discussed above, comparison of limited lethality data suggests that the safety index for these agents is quitenarrow in Rana pipiens. Analgesic use in laboratory Xenopus has the added risk of drowning due to over sedation. Drug doses extrapolated from such studies and intended to provide pain relief in Xenopus should therefore be considered very carefully. An additional concern for laboratory Xenopus is that the effects of these agents on amphibian oogenesis, oocyte quality, and embryogenesis are unknown. As the numbers of laboratory Xenopus used in basic and biomedical research continues to increase, clinicalstudies that address all of these issues cannot come too soon.
机译：对较早发展的实验室物种的福利的意识增强，促使机构动物保健委员会，研究人员和实验动物兽医对在非洲爪蟾实验室进行手术后镇痛药的需求的询问增多。对皮脂蛙疼痛机制和调节的基础研究表明，两栖动物中阿片类药物，α_2-肾上腺素能药和非阿片类镇痛药的临床潜力。但是，尚未进行使用客观建立的两栖动物疼痛指数的临床研究，或在皮脂蛙或实验室爪蟾中进行药理研究。如上所述，有限杀伤力数据的比较表明，在皮脂蛙中，这些药剂的安全性指标相当狭窄。在实验室非洲爪蟾中使用镇痛剂会增加由于过度镇静而导致溺水的风险。因此，应非常谨慎地考虑从此类研究推断出的，旨在缓解爪蟾镇痛的药物剂量。实验室爪蟾的另一个担忧是这些试剂对两栖动物卵子发生，卵母细胞质量和胚胎发生的影响尚不清楚。随着基础和生物医学研究中使用的非洲爪蟾的数量不断增加，解决所有这些问题的临床研究不能太早。

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