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首页> 外文期刊>Comparative Medicine >Environmental enrichment of laboratory rodents: the answer depends on the question.
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Environmental enrichment of laboratory rodents: the answer depends on the question.

机译：实验室啮齿动物的环境富集：答案取决于问题。

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Efforts to refine the care and use of animals in research have been ongoing for many years and have led to general standardization of rodent models, particularly with regard to animal housing, genetics, and health status. Concurrently, numerous informal practices and recommendations have been promulgated with the laudable intent of promoting general animal wellbeing through so-called enrichment of the cage environment. However, the variety of housing conditions fostered by efforts at environmental enrichment (EE) complicates the goal of establishing standardized or even defined environments for laboratory rodents. Many studies over the years have sought to determine whether or how various enrichment strategies affect the behavior and physiology of laboratory rodents. The findings, conclusions, and interpretations of these studies are mixed, particularly with regard to their application across rodent species, strains, genders, and ages; whether or how they affect the animals and the science; and, in some cases, whether the effects are positive, negative, or neutral in terms of animal wellbeing. Crucial issues related to the application of EE in research settings include its poorly defined effect on the animals, the potential for increased variability in the data, poor definition across labs and in publications, and potential for animal or scientific harm. The complexities, uncertainties, interpretational conundrums, varying conclusions, and lack of consensus in the EE literature warrant careful assessment of the benefits and liabilities associated with implementing such interventions. Reliance on evidence, professional judgment, and performance standards are crucial in the development of EE strategies.
机译：多年来，一直在努力改善研究中对动物的照料和使用，并导致了啮齿动物模型的普遍标准化，特别是在动物住房，遗传学和健康状况方面。同时，已经颁布了许多非正式的实践和建议，其通过所谓的“笼养环境的丰富化”来促进一般动物的福祉是值得称赞的。但是，通过努力进行环境富集（EE）促进的各种居住条件使为实验室啮齿动物建立标准化甚至定义的环境的目标变得复杂。多年来的许多研究试图确定各种富集策略是否或如何影响实验室啮齿动物的行为和生理。这些研究的发现，结论和解释是混杂的，特别是在它们在啮齿动物物种，品系，性别和年龄上的应用方面。它们是否或如何影响动物和科学;在某些情况下，无论是对动物健康的影响，是正面的，负面的还是中性的。与EE在研究环境中的应用有关的关键问题包括其对动物的定义不明确，数据变异性增加的可能性，实验室和出版物中的定义不清晰以及对动物或科学的危害。 EE文献中的复杂性，不确定性，解释难题，结论不一以及缺乏共识，需要仔细评估与实施此类干预措施相关的收益和责任。依赖证据，专业判断和绩效标准对于EE策略的开发至关重要。

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