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首页> 外文期刊>Comparative Medicine >Murine Norovirus Increases Atherosclerotic Lesion Size and Macrophages in Ldlr(-/-) Mice
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Murine Norovirus Increases Atherosclerotic Lesion Size and Macrophages in Ldlr(-/-) Mice

机译：鼠诺如病毒增加Ldlr（-/-）小鼠的动脉粥样硬化病变大小和巨噬细胞。

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Murine norovirus (MNV) is prevalent in rodent facilities in the United States. Because MNV has a tropism for macrophages and dendritic cells, we hypothesized that it may alter phenotypes of murine models of inflammatory diseases, such as obesity and atherosclerosis. We examined whether MNV infection influences phenotypes associated with diet-induced obesity and atherosclerosis by using Ldlr(-/-) mice. Male Ldlr(-/-) mice were maintained on either a diabetogenic or high-fat diet for 16 wk, inoculated with either MNV or vehicle, and monitored for changes in body weight, blood glucose, glucose tolerance, and insulin sensitivity. Influence of MNV on atherosclerosis was analyzed by determining aortic sinus lesion area. Under both dietary regimens, MNV-infected and control mice gained similar amounts of weight and developed similar degrees of insulin resistance. However, MNV infection was associated with significant increases in aortic sinus lesion area and macrophage content in Ldlr(-/-) mice fed a high-fat diet but not those fed a diabetogenic diet. In conclusion, MNV infection exacerbates atherosclerosis in Ldlr(-/-) mice fed a high-fat diet but does not influence obesity- and diabetes-related phenotypes. Increased lesion size was associated with increased macrophages, suggesting that MNV may influence macrophage activation or accumulation in the lesion area.
机译：鼠诺如病毒（MNV）在美国的啮齿动物设施中很普遍。由于MNV对巨噬细胞和树突状细胞具有嗜性，我们假设它可能会改变鼠类炎性疾病（如肥胖症和动脉粥样硬化）模型的表型。我们通过使用Ldlr（-/-）小鼠检查了MNV感染是否影响与饮食诱导的肥胖和动脉粥样硬化相关的表型。雄性Ldlr（-/-）小鼠维持糖尿病饮食或高脂饮食16周，接种MNV或溶媒，并监测体重，血糖，葡萄糖耐量和胰岛素敏感性的变化。通过确定主动脉窦病变区域来分析MNV对动脉粥样硬化的影响。在两种饮食方案下，感染MNV的小鼠和对照小鼠的体重相似，并且胰岛素抵抗程度相似。但是，MNV感染与饲喂高脂饮食的Ldlr（-/-）小鼠的主动脉窦病变面积和巨噬细胞含量显着增加有关，而与非糖尿病饮食的小鼠无关。总之，MNV感染会加剧高脂饮食喂养的Ldlr（-/-）小鼠的动脉粥样硬化，但不会影响与肥胖和糖尿病相关的表型。病变大小的增加与巨噬细胞的增加有关，这表明MNV可能影响巨噬细胞在病变区域的激活或积累。

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