• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Comparative Medicine >Echocardiographic Characterization of a Murine Model of Hypertrophic Obstructive Cardiomyopathy Induced by Cardiac-specific Overexpression of Epidermal Growth Factor Receptor 2
【24h】

Echocardiographic Characterization of a Murine Model of Hypertrophic Obstructive Cardiomyopathy Induced by Cardiac-specific Overexpression of Epidermal Growth Factor Receptor 2

机译：心脏特异表皮生长因子受体2诱导的肥厚性梗阻性心肌病的小鼠模型的超声心动图特征。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although rare, hypertrophic cardiomyopathy (HCM) with midventricular obstruction is often associated with severe symptoms and complications. None of the existing HCM animal models display this particular phenotype. Our group developed a mouse line that overexpresses the ErbB2 receptor (ErbB2(tg)) in cardiomyocytes; we previously showed that the ErbB2 receptor induces cardiomyocyte hypertrophy, myocyte disarray, and fibrosis compatible with HCM. In the current study, we sought to further echocardiographically characterize the ErbB2(tg) mouse line as a model of HCM. Compared with their wild-type littermates, ErbB2(tg) mice show increased left ventricular (LV) mass, concentric LV hypertrophy, and papillary muscle hypertrophy. This hypertrophy was accompanied by diastolic dysfunction, expressed as reduced E:A ratio, prolonged deceleration time, and elevated E:e' ratio. In addition, ErbB2(tg) mice consistently showed midcavity obstruction with elevated LV gradients, and the flow profile revealed a prolonged pressure increase and a delayed peak, indicating dynamic obstruction. The ejection fraction was increased in ErbB2(tg) mice, due to reduced end-diastolic and end-systolic LV volumes. Furthermore, systolic radial strain and systolic radial strain rate but not systolic circumferential strain and longitudinal strain were decreased in ErbB2(tg) compared with wild-type mice. In conclusion, the phenotype of the ErbB2(tg)mouse model is consistent with midventricular HCM in many important aspects, including massive LV hypertrophy, diastolic dysfunction, and midcavity obstruction. This pattern is unique for a small animal model, suggesting that ErbB2(tg) mice may be well suited for research into the hemodynamics and treatment of this rare form of HCM.
机译：尽管罕见，肥厚型心肌病（HCM）伴有脑室中部梗阻通常与严重的症状和并发症相关。现有的HCM动物模型均未显示该特定表型。我们的小组开发了一种在心肌细胞中过表达ErbB2受体（ErbB2（tg））的小鼠品系。我们之前的研究表明，ErbB2受体可诱导心肌肥大，心肌细胞紊乱以及与HCM相容的纤维化。在当前的研究中，我们试图进一步超声心动图表征ErbB2（tg）小鼠系作为HCM的模型。与野生型同窝仔相比，ErbB2（tg）小鼠显示出左心室（LV）质量增加，同心LV肥大和乳头肌肥大。这种肥大伴有舒张功能障碍，表现为E：A比率降低，减速时间延长和E：e'比率升高。此外，ErbB2（tg）小鼠持续显示中腔阻塞，LV梯度升高，血流曲线显示压力增加延长和峰延迟，表明存在动态阻塞。由于舒张末期和收缩末期LV体积减少，ErbB2（tg）小鼠的射血分数增加。此外，与野生型小鼠相比，ErbB2（tg）的收缩期径向应变和收缩期径向应变率降低，但收缩期周向应变和纵向应变均未降低。总之，ErbB2（tg）小鼠模型的表型在许多重要方面与心室HCM一致，包括大量左室肥大，舒张功能障碍和中腔阻塞。这种模式对于小型动物模型是唯一的，表明ErbB2（tg）小鼠可能非常适合于研究这种稀有形式的HCM的血流动力学和治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号