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The Physiologic Responses of Dutch Belted Rabbits Infected with Inhalational Anthrax

机译：荷兰腰带吸入性炭疽感染的生理反应

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摘要

Bacillus anihracis, the causative agent of anthrax, is a category A priority pathogen that causes extensive damage in humans. For this reason, B. anihracis has been the focus of numerous studies using various animal models. In this study, we exploredphysiologic parameters in Dutch belted rabbits with inhalation anthrax to characterize the disease progression in this model. To this end, we infected Dutch belted rabbits with 100 LD_(50) B. anihracis Ames spores by nasal instillation and continuously recorded various physiologic parameters by using telemetry. In addition, samples were collected at selected times for serum chemistry, hematology, and blood gas analysis. The animals exhibited hemodynamic and respiratory changes that coincided with thosereported in human cases of inhalational anthrax infection, including hypotension, altered heart rate, and respiratory distress. Likewise, hematology, serum chemistry, and blood gas analysis revealed trends comparable to human anthrax-related pathophysiology. The Dutch belted rabbit model of inhalational anthrax exhibited most of the physiologic, hematologic, and biochemical sequelae noted in human cases. Therefore, this rabbit model fulfills several of the criteria of a useful animal model for studyingdisease pathogenesis and evaluating therapeutics during inhalational anthrax.
机译：炭疽杆菌是炭疽的病原体，是引起人类广泛伤害的A类优先病原体。由于这个原因，B。anihracis已成为使用各种动物模型进行的众多研究的焦点。在这项研究中，我们探索了吸入性炭疽病的荷兰腰带兔子的生理参数，以表征该模型中疾病的进展。为此，我们通过鼻腔滴注用100 LD_（50）苯丙酸杆菌Ames孢子感染了荷兰带状兔子，并通过遥测技术连续记录了各种生理参数。另外，在选定的时间收集样品用于血清化学，血液学和血气分析。这些动物表现出的血液动力学和呼吸变化与人类吸入性炭疽感染病例的报告相吻合，包括低血压，心率改变和呼吸窘迫。同样，血液学，血清化学和血气分析揭示了与人类炭疽相关病理生理学相当的趋势。荷兰带状吸入性炭疽的兔子模型在人类病例中表现出大多数生理，血液和生化后遗症。因此，该兔子模型满足了用于研究吸入性炭疽病发病机理和评估治疗方法的有用动物模型的几个标准。

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