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首页> 外文期刊>Comparative Medicine >Magnetic Resonance Imaging (MRI) Assessment of Ventricular Remodeling after Myocardial Infarction in Rabbits
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Magnetic Resonance Imaging (MRI) Assessment of Ventricular Remodeling after Myocardial Infarction in Rabbits

机译：磁共振成像（MRI）评估兔心肌梗死后心室重构

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摘要

To understand the structure-function relationship in the postinfarcted myocardium in rabbits, we induced cardiac ischemia by ligating the left circumflex coronary artery. Sham controls underwent thoracotomy only. At 7 and 30 d after ligation, cardiac MRI was conducted by using pulse-oxymetry-gated cine acquisition to provide complete phases of the heartbeat. The rabbits were anesthetized under 1.5% isoflurane ventilation, and ultrafast techniques made breath-hold 3D coverage in different cardiac axes feasible. Viability imaging was performed after intravenous injection of 0.15 mmol/kg gadolinium to assess the extent of infarction. Data (n >= 6) are presented as mean SEM and analyzed by ANOVA and ANCOVA. In postligation rabbits, end-systolic (mean +/- SEM, 2.3 +/- 0.3 mL) and end-diastolic (4.2 +/- 0.4 mL) volumes were increased compared with preligation values (end-systolic, 1.1 +/- 0.1 mL; end-diastolic, 2.98 +/- 0.2 mL). Ejection fraction was influenced adversely by the presence of scar tissue at both 7 and 30 d after ligation and apparently nonlinear with the heart rate. Cardiac force was increased in the basal region in both end-systole and end-diastole in postligation hearts but progressively decreased toward the apex. Late gadolinium enhancement delineated 15.2 +/- 5.8% myocardial infarction at 7 d after ligation and 14.5 +/- 5.8% at 30 d, with limited wall motion and wall thinness. Compensatory wall thickening was present in the basal region when compared with that in preligation hearts. MRI offers detailed spatial resolution and tissue characterization after myocardial infarction.
机译：为了了解家兔梗死后心肌的结构-功能关系，我们结扎了左旋支冠状动脉，诱发了心肌缺血。假手术仅进行开胸手术。结扎后7和30 d，通过脉搏血氧定量门控电影采集进行心脏MRI，以提供完整的心跳相位。在1.5％的异氟烷​​通气下对兔子进行麻醉，超快技术使在不同心脏轴上屏住呼吸的3D覆盖成为可能。静脉内注射0.15 mmol / kg lin后进行生存力成像，以评估梗塞程度。数据（n> = 6）表示为平均SEM，并通过ANOVA和ANCOVA进行分析。结扎后家兔的收缩末期（平均+/- SEM，2.3 +/- 0.3 mL）和舒张末期（4.2 +/- 0.4 mL）的体积比结扎前值（收缩期，1.1 +/- 0.1）增加mL;舒张末期2.98 +/- 0.2 mL）。结扎后7和30 d，瘢痕组织的存在对射血分数有不利影响，并且明显与心率呈非线性关系。结扎后心脏的收缩末期和舒张末期的基底区域心脏力量增加，但向心尖逐渐减少。 g的晚期增强在结扎后7 d描绘出15.2 +/- 5.8％的心肌梗塞，在30 d描绘出14.5 +/- 5.8％的心肌梗塞，其壁运动和壁薄度有限。与结扎心脏相比，基底区域存在代偿性壁增厚。 MRI可提供详细的空间分辨率和心肌梗死后的组织特征。

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