Iron deficiency is the most common nutritional disorder. Children and pregnant women are at highest risk for developing iron deficiency because of their increased iron requirements. Iron-deficiency anemia during pregnancy is associated with adverse effects on fetal development, including low birth weight, growth retardation, hypertension, intrauterine fetal death, neurologic impairment, and premature birth. We hypothesized that pregnant mice fed an iron-deficient diet would have a similar outcome regarding fetal growth to that of humans. To this end, we randomly assigned female C57BL/6 mice to consume 1 of 4 diets (high-iron-low-bioavailability, high-iron-high-bioavailability, iron-replete, and iron-deficient) for 4 wk before breeding, followed by euthanasia on day 17 to 18 of gestation. Compared with all other groups, dams fed the high-iron-high-bioavailability diet had significantly higher liver iron. Hct and Hgb levels in dams fed the iron-deficient diet were decreased by at least 2.5 g/dL as compared with those of all other groups. In addition, the percentage of viable pups among dams fed the iron-deficient diet was lower than that of all other groups. Finally, compared with all other groups, fetuses from dams fed the iron-deficient diet had lower fetal brain iron levels, shorter crown-rump lengths, and lower weights. In summary, mice fed an iron-deficient diet had similar hematologic values and fetal outcomes as those of iron-deficient humans, making this a useful model for studying iron-deficiency anemia during pregnancy.
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机译：缺铁是最常见的营养失调。儿童和孕妇由于铁需求增加而患铁缺乏症的风险最高。怀孕期间缺铁性贫血与胎儿发育不良相关，包括低出生体重，发育迟缓，高血压，子宫内胎儿死亡，神经系统损害和早产。我们假设喂养缺铁饮食的怀孕小鼠在胎儿生长方面的结果与人类相似。为此，我们将雌性C57BL / 6小鼠随机分配为在繁殖前4周内进食4种饮食（高铁低生物利用度，高铁高生物利用度，铁充足和铁缺乏）中的1种，随后在妊娠第17至18天实施安乐死。与所有其他组相比，饲喂高铁高生物利用度饮食的水坝的肝铁含量明显更高。与所有其他组相比，饲喂缺铁饮食的大坝中的Hct和Hgb水平降低了至少2.5 g / dL。此外，饲喂缺铁饮食的大坝中成年幼崽的比例低于所有其他组。最后，与所有其他组相比，用铁缺乏饮食喂养的大坝胎儿的胎儿脑铁水平较低，冠臀长度较短，体重较轻。总之，饲喂缺铁饮食的小鼠的血液学价值和胎儿结局与缺铁人类相似，这使其成为研究妊娠期缺铁性贫血的有用模型。
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