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首页> 外文期刊>Comparative Medicine >Magnetic Resonance Imaging of the Response of a Mouse Model of Non-Small Cell Lung Cancer to Tyrosine Kinase Inhibitor Treatment.
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Magnetic Resonance Imaging of the Response of a Mouse Model of Non-Small Cell Lung Cancer to Tyrosine Kinase Inhibitor Treatment.

机译：非小细胞肺癌小鼠模型对酪氨酸激酶抑制剂治疗反应的磁共振成像。

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Mutational activation of the gene for epidermal growth factor receptor (EGFR) is 1 of the main ways by which this receptor induces non-small cell lung cancers (NSCLC). Variant III EGFR (EGFRvIII) is a potential therapeutic target in NSCLC treatment because of the high frequency of deletion mutations in this protein. This study used noninvasive magnetic resonance imaging (MRI) to investigate the role of an EGFRvIII mutant in lung tumorigenesis and tumor maintenance as well as its response to the EGFR small molecule inhibitor erlotinib (Tarceva) on bitransgenic mice. Both spin-echo and gradient-echo sequences with and without cardiac and respiratory gating were performed to image the invasive mouse lung tumor driven by EGFRvIII mutation. Tumor volumes were measured based on 2-dimensional axial MRI; 3-dimensional rendering of the images were obtained to demonstrate the spatial location and distribution of the tumor in the lung. The MRI results indicated that the tumor driven by the EGFRvIII mutation was generated and maintained in the bitransgenic mice with the use of doxycycline. Tumor monitoring via MRI showed that Erlotinib can significantly inhibit the growth of tumor in vivo. MRI has the ability to image mouse lung tumor with different sequences focusing on tissue contrasts between tumor and surroundings. The MRI approaches in this work can be applied on other antitumor drug treatment evaluation in vivo when appropriate sequences are chosen.
机译：表皮生长因子受体（EGFR）的基因突变激活是该受体诱导非小细胞肺癌（NSCLC）的主要方式之一。变体III EGFR（EGFRvIII）是NSCLC治疗中潜在的治疗靶标，因为该蛋白中的缺失突变频率很高。这项研究使用无创磁共振成像（MRI）来研究EGFRvIII突变体在肺肿瘤发生和肿瘤维持中的作用，以及它对双转基因小鼠中EGFR小分子抑制剂厄洛替尼（Tarceva）的反应。带有和不带有心脏和呼吸门控的自旋回波和梯度回波序列均用于成像由EGFRvIII突变驱动的侵袭性小鼠肺部肿瘤。基于二维轴向MRI测量肿瘤体积;获得图像的3维渲染以证明肿瘤在肺中的空间位置和分布。 MRI结果表明，使用强力霉素在双转基因小鼠中产生并维持了由EGFRvIII突变驱动的肿瘤。通过MRI进行的肿瘤监测显示，厄洛替尼可以在体内显着抑制肿瘤的生长。 MRI具有对小鼠肺部肿瘤进行成像的能力，该序列针对肿瘤和周围环境之间的组织对比的不同序列。选择适当的序列后，这项工作中的MRI方法可以应用于其他体内抗肿瘤药物治疗评估。

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