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首页> 外文期刊>Comparative Medicine >Fatigue and Sleep during Cancer and Chemotherapy: Translational Rodent Models.
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Fatigue and Sleep during Cancer and Chemotherapy: Translational Rodent Models.

机译：癌症和化学疗法中的疲劳和睡眠：转化型啮齿动物模型。

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摘要

The frequent occurrence of fatigue and disturbed sleep in cancer survivors and the negative effect of these symptoms on quality of life and clinical outcome underscore the need to identify mechanisms that cause cancer-related fatigue, with a view toward developing more effective treatments for this problem. Human studies of fatigue and disturbed sleep are limited by high interindividual genetic and environmental variability, difficulties with behavioral or reporting compliance, and the subjective nature of the problems. Although animal models also must overcome the barrier of assessing fatigue and sleep disturbance in the absence of obvious objective clinical markers, animal studies are easier to control and standardize than are studies of people. Moreover, animal models are crucial to the identification and understanding of underlying disease mechanisms. This review describes the need for, the feasibility of, and several possible approaches to measuring fatigue in animal models of cancer and to relating such measures to disturbed sleep, immune function, and other potential mechanisms. Developing and using animal models to better understand fatigue and disturbed sleep related to cancer and its treatment has an enormous potential to expand the knowledge base and foster hypotheses necessary for the future development and testing of interventions.
机译：癌症幸存者经常发生疲劳和睡眠障碍，这些症状对生活质量和临床结果产生负面影响，这突显了确定导致癌症相关疲劳的机制的必要性，以期寻求针对此问题的更有效治疗方法。人类对疲劳和睡眠障碍的研究受到个体间遗传和环境变异性高，行为或报告依从性困难以及问题的主观性质的限制。尽管在缺乏明显的客观临床指标的情况下，动物模型还必须克服评估疲劳和睡眠障碍的障碍，但动物研究比人类研究更容易控制和标准化。此外，动物模型对于识别和理解潜在疾病机制至关重要。这篇综述描述了在癌症动物模型中测量疲劳并将这种测量与睡眠障碍，免疫功能和其他潜在机制相关联的需求，可行性和几种可能的方法。开发和使用动物模型以更好地理解与癌症有关的疲劳和睡眠紊乱及其治疗方法具有巨大的潜力，可以扩展知识基础，并为今后的开发和测试干预措施建立必要的假设。

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