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首页> 外文期刊>Comparative Medicine >Sleep and temperature responses of inbred mice with Candida albicans-induced pyelonephritis
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Sleep and temperature responses of inbred mice with Candida albicans-induced pyelonephritis

机译：近亲念珠菌诱发的肾盂肾炎的睡眠和温度反应

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摘要

Human patients with renal disease frequently develop disturbed sleep and severe fatigue. To develop a model for studying factors that contribute to these symptoms, we characterized the sleep patterns of various strains of mice after acute challenge with the fungal organism Candida albicans. After intravenous administration to mice, C. albicans typically colonizes the kidney, producing acute pyelonephritis. Various strains of inbred mice demonstrate marked variation in the temperature and sleep responses that develop after challenge, with individual strains generally showing increased or reduced somnolence in association with fever or hypothermia, respectively. C. albicans-infected mice may be a useful model for identifying the genes and mechanisms that link sleep, temperature, fatigue, and the immune response.
机译：患有肾脏疾病的人类患者经常出现睡眠不佳和严重疲劳。要开发用于研究导致这些症状的因素的模型，我们表征了真菌白色念珠菌急性攻击后各种品系小鼠的睡眠模式。给小鼠静脉内给药后，白色念珠菌通常会定植于肾脏，从而产生急性肾盂肾炎。各种近交系小鼠在攻击后表现出温度和睡眠反应的显着变化，个别株系通常分别表现出与发烧或体温过低相关的嗜睡感增加或减少。感染白色念珠菌的小鼠可能是鉴定链接睡眠，温度，疲劳和免疫反应的基因和机制的有用模型。

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