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首页> 外文期刊>Comparative Medicine >Morphologic and biochemical changes caused by experimentally induced dicroceliosis in hamsters (Mesocricetus auratus)
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Morphologic and biochemical changes caused by experimentally induced dicroceliosis in hamsters (Mesocricetus auratus)

机译：实验性仓鼠梭菌病引起的形态和生化变化（Mesocricetus auratus）

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Background and Purpose: The aim of the study reported here was to investigate the pathomorphologic changes caused by experimentally induced dicroceliosis and their correlation with hepatobiliary function. Methods: Studies were carried out at days 80and 120 after oral inoculation of hamsters with 40 metacercariae of Dicrocoelium dendriticum. Results: The parasite-induced pathologic changes were assessed by presence of fluke eggs in feces, increased plasma alanine transaminase and aspartate transaminase activities and morphologic alterations. Dicroceliosis was characterized by bile ductular proliferation and enlargement of the bile duct surface area caused by hyperplastic cholangitis in septal bile ducts. The liver from infected animals contained portal tracts infiltrated with small to moderate numbers of lymphocytes macrophages, and eosinophils. Simultaneously, there was an increase in portal tract collagen that extended to the interlobular septa and caused pressure atrophy of the hepatic parenchyma. The concentration of thiobarbituric acid-reactive substances and the ratio of oxidized to reduced glutathione, measured as markers of oxidative stress, were significantly increased. Conclusions: The presence of oxidative alterations could be relatedto the morphologic evidence of chronic inflammatory response as well as to liver cellular injury indicated by cellular swelling, and increased presence of peroxisomes and lysosomes.
机译：背景与目的：本文报道的研究目的是研究实验性硬皮病引起的病理形态学变化及其与肝胆功能的相关性。方法：在口服接种仓鼠的40头meta草后，在第80天和第120天进行研究。结果：通过粪便中存在吸虫卵，血浆丙氨酸转氨酶和天冬氨酸转氨酶活性增加以及形态改变来评估寄生虫引起的病理变化。小腿坏死病的特征是中隔胆管增生性胆管炎引起的胆管增生和胆管表面积增大。来自被感染动物的肝脏包含的门道已被少量至中度的淋巴细胞巨噬细胞和嗜酸性粒细胞浸润。同时，门脉胶原蛋白增加到小叶间隔，并引起肝实质压力萎缩。硫代巴比妥酸反应性物质的浓度和氧化还原型谷胱甘肽的比例，作为氧化应激的标志物，显着增加。结论：氧化变化的存在可能与慢性炎症反应的形态学证据以及细胞肿胀表明的肝细胞损伤以及过氧化物酶体和溶酶体的存在有关。

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