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首页> 外文期刊>Comparative Medicine >Hearing in laboratory animals: strain differences and nonauditory effects of noise.
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Hearing in laboratory animals: strain differences and nonauditory effects of noise.

机译：实验动物的听力：应变差异和噪声的非听觉影响。

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Hearing in laboratory animals is a topic that traditionally has been the domain of the auditory researcher. However, hearing loss and exposure to various environmental sounds can lead to changes in multiple organ systems, making what laboratory animals hear of consequence for researchers beyond those solely interested in hearing. For example, several inbred mouse strains commonly used in biomedical research (e.g., C57BL/6, DBA/2, and BALB/c) experience a genetically determined, progressive hearing loss that can lead to secondary changes in systems ranging from brain neurochemistry to social behavior. Both researchers and laboratory animal facility personnel should be aware of both strain and species differences in hearing in order to minimize potentially confounding variables in their research and to aid in the interpretation of data. Independent of genetic differences, acoustic noise levels in laboratory animal facilities can have considerable effects on the inhabitants. A large body of literature describes the nonauditory impact of noise on the biology and behavior of various strains and species of laboratory animals. The broad systemic effects of noise exposure include changes in endocrine and cardiovascular function, sleep-wake cycle disturbances, seizure susceptibility, and an array of behavioral changes. These changes are determined partly by species and strain; partly by noise intensity level, duration, predictability, and other characteristics of the sound; and partly by animal history and exposure context. This article reviews some of the basic strain and species differences in hearing and outlines how the acoustic environment affects different mammals.
机译：传统上，实验动物的听力是听觉研究者的主题。但是，听力损失和暴露于各种环境声音会导致多个器官系统发生变化，这使得实验动物所听到的东西对那些只对听觉不感兴趣的研究人员产生了影响。例如，一些生物医学研究中常用的近交小鼠品系（例如C57BL / 6，DBA / 2和BALB / c）经历了遗传确定的进行性听力损失，可能导致从脑神经化学到社交疾病的系统发生二次变化行为。研究人员和实验室动物设施人员均应注意听觉中的品系和种类差异，以最大程度地减少研究中可能造成混淆的变量并帮助解释数据。独立于遗传差异，实验室动物设施中的噪声水平可能会对居民产生重大影响。大量文献描述了噪声对实验室动物各种菌株和物种的生物学和行为的非听觉影响。噪声暴露的广泛系统影响包括内分泌和心血管功能的变化，睡眠-觉醒周期障碍，癫痫发作易感性以及一系列行为变化。这些变化部分取决于物种和品系。部分取决于噪声强度水平，持续时间，可预测性和声音的其他特征;部分是由动物历史和接触环境决定的。本文回顾了听力中的一些基本菌株和物种差异，并概述了声学环境如何影响不同的哺乳动物。

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