• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Comparative Medicine >Birth of Rhesus Macaque (Macaca mulatta) Infants After In Vitro Fertilization and Gestation in Female Rhesus or Pigtailed (Macaca nemestrina) Macaques
【24h】

Birth of Rhesus Macaque (Macaca mulatta) Infants After In Vitro Fertilization and Gestation in Female Rhesus or Pigtailed (Macaca nemestrina) Macaques

机译：猕猴或猪尾猕猴体外受精和妊娠后恒河猴（猕猴）的出生

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A study was conducted to assess the possibility of using pigtailed macaques (Macaca nemestrina) as recipients for rhesus macaque (Macaca mulatta) embryos. A total of 250 oocytes were collected from 11 rhesus monkeys during 12 follicular aspirations. We performed 15 embryo transfers with two embryos each into rhesus recipients, which resulted in eight pregnancies, of which two were lost during the second trimester. Among the remaining six pregnant rhesus macaques, two were carrying twins, resulting in the birth of eight infants. Twelve transfers of rhesus embryos into pigtailed macaques resulted in one pregnancy and the birth of one infant. Fetal growth and development were monitored by monthly ultrasound examinations, during which biparietal measurements were taken and compared with those derived from 22 pregnant control monkeys. In vitro fertilization-derived singletons tended to develop faster than did twins and naturally conceived control singletons during the initial months of pregnancy and weighed more at birth than did twins. There were pronounced morphologic changes in the placenta of the rhesus that developed in the female pigtailed macaque. These included an irregular shape, elevated placenta-to-birth-weight ratio, and an abnormal length and diameter of the umbilical cord. Histologic analyses of the rhesus-pigtailed placenta showed evidence of maternal-placental floor infarction and thrombosis of the spiral artery with resulting infarction of the villi. These results demonstrate that pigtailed macaques can carry rhesus fetuses to term, but further studies are necessary to determine the cause of the decreased pregnancy rates and observed placental abnormalities.
机译：进行了一项研究，以评估使用尾纤猕猴（Macaca nemestrina）作为恒河猴（Macaca mulatta）胚胎的接受者的可能性。在12次滤泡抽吸期间，从11只恒河猴收集了250个卵母细胞。我们进行了15次胚胎移植，每个胚胎有两个胚胎进入恒河猴受体，这导致了8次怀孕，其中两个在孕中期丢失。在其余六只怀孕的恒河猴中，有两只携带双胞胎，导致八个婴儿的出生。十二次将恒河猴胚胎转移到尾巴猕猴中，导致一名孕妇和一名婴儿的出生。通过每月超声检查监测胎儿的生长和发育，在此期间进行双顶测量并与22只怀孕的对照猴子进行比较。体外受精的单身人士往往比双胞胎发育更快，并且在怀孕的最初几个月自然就想到了对照单身人士，并且出生时的体重比双胞胎要重。在雌性猪尾猕猴中出现的恒河胎盘有明显的形态学变化。这些包括形状不规则，胎盘与出生体重的比例升高以及脐带的长度和直径异常。恒河猴尾胎盘的组织学分析表明，母胎盘底梗塞和螺旋动脉血栓形成导致绒毛梗塞。这些结果表明，辫状猕猴可以将恒河猴胎儿带到足月，但需要进一步的研究以确定怀孕率降低和胎盘异常的原因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号