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首页> 外文期刊>Comparative Medicine >Metabolic Syndrome and Coronary Artery Disease in Ossabaw Compared with Yucatan Swine
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Metabolic Syndrome and Coronary Artery Disease in Ossabaw Compared with Yucatan Swine

机译：与尤卡坦猪相比，Ossabaw的代谢综合征和冠状动脉疾病

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Metabolic syndrome (MetS), a compilation of associated risk factors, increases the risk of type 2 diabetes and coronary artery disease (CAD, atherosclerosis), which can progress to the point of artery occlusion. Stents are the primary interventional treatment for occlusive CAD, and patients with MetS and hyperinsulinemia have increased restenosis. Because of its thrifty genotype, the Ossabaw pig is a model of MetS. We tested the hypothesis that, when fed high-fat diet, Ossabaw swine develop more features of MetS, greater native CAD, and greater stent-induced CAD than do Yucatan swine. Animals of each breed were divided randomly into 2 groups and fed 2 different calorie-matched diets for 40 wk: control diet (C) and high-fat, high-cholesterol atherogenic diet (H). A bare metal stent was placed in the circumflex artery, and pigs were allowed to recover for 3 wk. Characteristics of MetS, macrovascular and microvascular CAD, in-stent stenosis, and Ca2+ signaling in coronary smooth muscle cells were evaluated. MetS characteristics including, obesity, glucose intolerance, hyperinsulinemia, and elevated arterial pressure were elevated in Ossabaw swine compared to Yucatan swine. Ossabaw swine with MetS had more extensive and diffuse native CAD and in-stent stenosis and impaired coronary blood flow regulation compared with Yucatan. In-stent atherosclerotic lesions in Ossabaw coronary arteries were less fibrous and more cellular. Coronary smooth muscle cells from Ossabaw had impaired Ca2+ efflux and intracellular sequestration versus cells from Yucatan swine. Therefore, Ossabaw swine are a superior model of MetS, subsequent CAD, and cellular Ca2+ signaling defects, whereas Yucatan swine are leaner and relatively resistant to MetS and CAD.
机译：代谢综合症（MetS）是一组相关的风险因素，会增加2型糖尿病和冠状动脉疾病（CAD，动脉粥样硬化）的风险，这种疾病可能发展为动脉闭塞。支架是闭塞性CAD的主要介入治疗方法，MetS和高胰岛素血症患者的再狭窄增加。由于节俭基因型，Ossabaw猪是MetS的模型。我们检验了以下假设：与尤卡坦猪相比，当以高脂饮食喂养时，Ossabaw猪具有更多的MetS功能，更大的天然CAD和更大的支架诱导CAD。将每个品种的动物随机分为2组，以40 wk喂养2种不同的卡路里匹配饮食：对照饮食（C）和高脂，高胆固醇动脉粥样化饮食（H）。将裸露的金属支架放置在回旋动脉中，让猪恢复3周。评估了MetS，大血管和微血管CAD，支架内狭窄和冠状动脉平滑肌细胞内Ca2 +信号传导的特征。与尤加坦猪相比，Ossabaw猪的MetS特征包括肥胖，葡萄糖耐量异常，高胰岛素血症和动脉压升高。与尤卡坦州相比，具有MetS的Ossabaw猪具有更广泛和分散的天然CAD和支架内狭窄以及冠状动脉血流调节受损。 Ossabaw冠状动脉的支架内动脉粥样硬化病变纤维较少，细胞较多。与来自尤卡坦猪的细胞相比，来自奥斯萨巴的冠状平滑肌细胞的Ca2 +外流和细胞内螯合受损。因此，Ossabaw猪是MetS，随后的CAD和细胞Ca2 +信号缺陷的优良模型，而Yucatan猪则更苗条并且对MetS和CAD具有相对的抵抗力。

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