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Endpoints in Myelin-Deficient (md) Rats

机译：髓磷脂缺乏（md）大鼠的终点

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Health problems in some animal models remain unexplained, rendering in vivo studies ethically challenging, especially when experimental animals are prone to sudden death. Over the last 3 decades, the myelin-deficient (id) rat, a strain with severe dysmyelination due to mutant proteolipid protein, has been key to important discoveries in mechanisms of myelination and glial cell biology. The usefulness of this mutant rat, however, has been limited by sudden death during the fourth week of life. Timely euthanasia has been difficult because the cause of these mortalities remains unexplained and the endpoint not determined. In this clinicopathologic study, we determined that sudden onset of hindlimb paralysis inevitably leads to paralysis of the urinary bladder and then breathing difficulties because of severe injury to the spinal cord in the midthoracic region with concurrent narrowing of the vertebral canal due to fracture of a vertebral body. Sudden onset of hindlimb paralysis likely is related to seizures and severe muscle spasms that begin to occur at the end of the third week of life. Once seizure activity begins, we recommend frequent monitoring of md rats for hindlimb paralysis and distention of the urinary bladder as indication of endpoints mandating prompt euthanasia.
机译：某些动物模型中的健康问题仍然无法解释，这使得体内研究在伦理上具有挑战性，特别是当实验动物容易猝死时。在过去的30年中，髓磷脂缺乏症（id）大鼠是一种因突变的蛋白脂蛋白而导致严重髓鞘异常的菌株，一直是髓鞘形成和神经胶质细胞生物学机制中重要发现的关键。然而，这种突变大鼠的用处受到生命第四周突然死亡的限制。及时的安乐死是困难的，因为这些死亡的原因仍然无法解释，终点没有确定。在这项临床病理学研究中，我们确定后肢麻痹的突然发作不可避免地导致膀胱麻痹，然后由于胸中部区域脊髓受到严重损伤并由于椎骨骨折导致椎管狭窄而导致呼吸困难身体。后肢瘫痪的突然发作可能与癫痫发作和严重的肌肉痉挛有关，这种发作在生命的第三周结束时开始发生。一旦癫痫发作开始，我们建议对md大鼠进行频繁监测，以观察其后肢麻痹和膀胱扩张，以作为提示实施快速安乐死的指标。

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