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Mouse models of prostate cancer

机译：前列腺癌的小鼠模型

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Human prostate cancer (CAP) is classically a highly androgen-dependent cancer that will eventually transform to androgen independence. Although there is wide heterogeneity in the phenotype of CaP cancers, most of them have a classic micmacinar growthpattern of cells containing prominent single nucleoli. The tumor has a propensity for perineural infiltration, and aggressive local invasion. Metastasis involves regional (pelvic) lymph nodes and bone where, classically, it induces osteoblastic reactions. The goals of creating genetically engineered mouse (GEM) models of CaP are to model the important transition points in the human disease, namely, the initiating events, the transition from in situ to invasive, the transition from localized to metastatic, and the transition to androgen independence. Also critical to mouse modeling of CaP is mimicry of the phenotype as well as the molecular events seen in human disease progression.
机译：传统上，人类前列腺癌（CAP）是高度依赖雄激素的癌症，最终将转变为雄激素独立性。尽管CaP癌症的表型具有广泛的异质性，但大多数都具有包含突出的单个核仁的细胞的经典micmacinar生长模式。肿瘤倾向于神经周浸润和侵袭性局部浸润。转移涉及区域（骨盆）淋巴结和骨骼，在经典情况下，转移会诱导成骨细胞反应。创建CaP的基因工程小鼠（GEM）模型的目的是为人类疾病中的重要转变点建模，即起始事件，从原位转变为侵入性转变，从局部转变为转移性转变以及向雄激素独立性。对CaP小鼠建模同样重要的是表型的模仿以及人类疾病进展中发现的分子事件。

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