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首页> 外文期刊>Comparative Medicine >Ovine intestinal adenocarcinomas: histologic and phenotypic comparison with human colon cancer.
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Ovine intestinal adenocarcinomas: histologic and phenotypic comparison with human colon cancer.

机译：绵羊肠腺癌：与人类结肠癌的组织学和表型比较。

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Approximately 7% of old, unthrifty sheep (Ovis aries) in New Zealand have intestinal adenocarcinomas. To investigate whether these sheep might be used as a model of human colonic neoplasia, the biologic behavior and histologic appearance of ovine intestinal adenocarcinomas were compared with those reported for human colonic adenocarcinomas. We collected 50 intestinal tracts with grossly visible intestinal neoplasia from slaughtered sheep. Neoplasms were assessed using World Health Organization guidelines for assessment of human colonic adenocarcinomas. All ovine adenocarcinomas developed in the small intestine. In contrast, only 4% of human intestinal tumors develop at this location, whereas the majority develop in the colon. A visible polyp is present within 89% of human colonic adenocarcinomas, whereas polyps were present in only 46% of the ovine neoplasms. Intestinal wall infiltration by the neoplastic cells and rates of lymph node (84% in sheep; 61% in humans) and distant (52% in sheep; 17% in humans) metastases were comparable between ovine and human adenocarcinomas. However, ovine adenocarcinomas developed more peritoneal and fewer hepatic metastases than human adenocarcinomas. Histologic grading of ovine tumors revealed cell differentiation similar to that reported within human colonic adenocarcinomas. In conclusion, ovine intestinal adenocarcinomas, like human colonic adenocarcinomas, typically arise spontaneously and consistently develop widespread metastases. In addition, tumors appear histologically similar between these species. Therefore, sheep may provide a model of advanced human colonic cancer, possibly allowing evaluation of novel therapeutics and surgical procedures..
机译：在新西兰，约有7％的陈旧节俭绵羊（Ovis aries）患有肠腺癌。为了研究这些绵羊是否可以用作人类结肠癌的模型，将绵羊肠道腺癌的生物学行为和组织学表现与人类结肠腺癌的报道进行了比较。我们从屠宰的绵羊中收集了50条肠道肉眼可见的肠肿瘤。使用世界卫生组织的指南评估肿瘤，以评估人类结肠腺癌。所有绵羊腺癌都在小肠内形成。相比之下，只有4％的人类肠道肿瘤在此位置发展，而大多数在结肠中发展。可见的息肉存在于人类结肠腺癌的89％中，而息肉仅存在于46％的绵羊肿瘤中。绵羊和人腺癌之间肿瘤细胞对肠壁的浸润和淋巴结转移率（绵羊为84％;人类为61％）和远处（绵羊为52％;人类为17％）的转移率相当。但是，绵羊腺癌比人腺癌发展出更多的腹膜和更少的肝转移。绵羊肿瘤的组织学分级显示与人结肠腺癌中报道的细胞分化相似。总之，像人结肠腺癌一样，绵羊肠腺癌通常会自发发生并持续发生广泛的转移。另外，这些物种之间的肿瘤在组织学上看起来相似。因此，绵羊可以提供晚期人类结肠癌的模型，可能允许评估新的治疗方法和手术程序。

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