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首页> 外文期刊>Biology of Reproduction: Offical Journal of the Society for the Study of Reproduction >Onset and progress of meiotic prophase in the oocytes in the B6. Y-TIR sex-reversed mouse ovary
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Onset and progress of meiotic prophase in the oocytes in the B6. Y-TIR sex-reversed mouse ovary

机译：B6卵母细胞中减数分裂前期的发生和进展。 Y-TIR性别逆转小鼠卵巢

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摘要

When the Y chromosome of a Mus musculus domesticus male mouse (caught in Tirano, Italy) is placed on a C57BL/6J genetic background, approximately half of the XY (B6.Y-TIR) progeny develop into normal-appearing but infertile females. We have previously reported that the primary cause of infertility can be attributed to their oocytes. To identify the primary defect in the XY oocyte, we examined the onset and progress of meiotic prophase in the B6.Y-TIR fetal ovary. Using bromo-deoxyuridine incorporation and culture, we determined that the germ cells began to enter meiosis at the developmental ages and in numbers comparable to those in the control XX ovary. Furthermore, the meiotic prophase appeared to progress normally until the late zygotene stage. However, the oocytes that entered meiosis early in the XY ovary failed to complete the meiotic prophase. On the other hand, a considerable number of oocytes entered meiosis at late developmental stages and completed the meiotic prophase in the XY ovary. We propose that the timing of entry into meiosis and the XY chromosomal composition influence the survival of oocytes during meiotic prophase in the fetal ovary. [References: 28]
机译：当将家鼠小家鼠（在意大利的蒂拉诺抓到）的Y染色体置于C57BL / 6J遗传背景上时，大约一半的XY（B6.Y-TIR）子代发育成外观正常但不育的雌性。我们以前曾报道过，不孕的主要原因可归因于它们的卵母细胞。为了确定XY卵母细胞的主要缺陷，我们检查了B6.Y-TIR胎儿卵巢中减数分裂前期的发生和进展。使用溴脱氧尿苷掺入和培养，我们确定生殖细胞在发育年龄开始进入减数分裂，其数量与对照组XX卵巢相当。此外，减数分裂的前期似乎正常进行直至合子期晚期。但是，在XY卵巢早期进入减数分裂的卵母细胞无法完成减数分裂前期。另一方面，相当多的卵母细胞在发育后期进入减数分裂并完成了XY卵巢的减数分裂前期。我们建议进入减数分裂的时机和XY染色体组成影响胎儿卵巢减数分裂前期卵母细胞的存活。 [参考：28]

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