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Principles of Research Tissue Banking and Specimen Evaluation from the Pathologist's Perspective

机译：病理学家视角下的研究组织储备和标本评估原理

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摘要

Human tissue biorepositories have an increasingly visible and important role within industrial enterprises in supporting biomedical research, including the rapidly advancing fields of proteomics, pharmacogenomics, and molecular epidemiology. Pathologists play a vital but often underrecognized role in the operation of these tissue banks. Besides interpreting studies that arise from banked samples, pathologists are needed to characterize tissues for research, to conduct quality assurance programs, to assist with resource allocation decisions, and to serve an educational role for investigators using the tissues. This article describes these key principles and illustrates examples where pathologist involvement is crucial to biorepository management. Of overarching importance, pathologists play a critical role in helping biorepository users understand the principles of specimen evaluation (histologic and structural composition of tissues, and their limitations) so as to optimize the scientific benefit of the tissues. In conclusion, greater involvement of pathologists in research tissue banking will enhance the scientific utility of biorepositories.
机译：在支持生物医学研究（包括蛋白质组学，药物基因组学和分子流行病学等迅速发展的领域）的工业企业中，人体组织生物库具有越来越明显的重要作用。病理学家在这些组织库的操作中起着至关重要的作用，但常常被人们忽视。除了解释来自样本库的研究之外，病理学家还需要表征组织以进行研究，进行质量保证计划，协助进行资源分配决策并为使用组织的研究人员发挥教育作用。本文介绍了这些关键原则，并举例说明了病理学家的参与对生物存储库管理至关重要的例子。至关重要的是，病理学家在帮助生物存储库用户了解标本评估的原理（组织的组织学和结构组成及其局限性），从而优化组织的科学效益方面发挥着至关重要的作用。总之，病理学家更多地参与组织研究的研究将增强生物存储库的科学实用性。

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