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A Proposed Schema for Classifying Human Research Biobanks

机译:拟议的人类研究生物库分类方案

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Human research biobanks have rapidly expanded in the past 20 years, in terms of both their complexity and utility. To date there exists no agreement upon classification schema for these biobanks. This is an important issue to address for several reasons: to ensure that the diversity of biobanks is appreciated, to assist researchers in understanding what type of biobank they need access to, and to help institutions/funding bodies appreciate the varying level of support required for different types of biobanks. To capture the degree of complexity, specialization, and diversity that exists among human research biobanks, we propose here a new classification schema achieved using a conceptual classification approach. This schema is based on 4 functional biobank "elements" (donor/participant, design, biospecimens, and brand), which we feel are most important to the major stakeholder groups (public/participants, members of the biobank community, health care professionals/ researcher users, sponsors/funders, and oversight bodies), and multiple intrinsic features or "subelements" (eg, the element "biospecimens" could be further classified based on preservation method into fixed, frozen, fresh, live, and desiccated). We further propose that the subelements relating to design (scale, accrual, data format, and data content) and brand (user, leadership, and sponsor) should be specifically recognized by individual biobanks and included in their communications to the broad stakeholder audience.
机译:就复杂性和实用性而言,人类研究生物库在过去20年中迅速发展。迄今为止,对于这些生物库的分类方案尚无共识。这是一个要解决的重要问题,其原因有以下几种:确保赞赏生物库的多样性,帮助研究人员了解他们需要使用哪种类型的生物库,并帮助机构/资助机构理解为获得支持而需要的不同水平的支持。不同类型的生物库。为了捕获人类研究生物库之间存在的复杂性,专业化和多样性的程度,我们在这里提出一种使用概念分类方法实现的新分类方案。此架构基于4个功能性生物库“元素”(捐赠者/参与者,设计,生物样本和品牌),我们认为这对主要利益相关者群体(公众/参与者,生物库社区成员,医疗保健专业人员/研究者用户,赞助者/资助者和监督机构)以及多个内在特征或“子元素”(例如,“生物标本”元素可以根据保存方法进一步分为固定,冷冻,新鲜,鲜活和干燥)。我们进一步建议,与设计(规模,权责发生制,数据格式和数据内容)和品牌(用户,领导层和赞助商)有关的子元素应由各个生物银行明确认可,并包括在与广大利益相关者的交流中。

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