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首页> 外文期刊>Comparative parasitology >The Course of a 300 Metacercarial Infection of Echinostoma caproni (Digenea: Echinostomatidae) in Institute for Cancer Research (ICR) Mice
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The Course of a 300 Metacercarial Infection of Echinostoma caproni (Digenea: Echinostomatidae) in Institute for Cancer Research (ICR) Mice

机译：癌症研究所（ICR）小鼠的300头棘孢棘皮Meta肠Meta虫感染（双基因：棘皮mat科）的病程

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The course of a 300 metacercarial infection of ICR mice with Echinostoma caproni was examined over a 24-d period. Seven groups of 3 mice each were infected with 300 metacercariae of E. caproni and examined at 24 hr postinfection (PI), 4 d PI, and then at 4-d intervals to 24 d PI; however, as a result of the death of 4 mice prior to necropsy, the 20-d collection was abandoned. All mice were infected at the time of examination with worm loads ranging from 13.3% to 94.3% of the initial inoculum. The lowest recovery was at 24 hr PI with an average of 26.7% and the majority of worms located in the posterior one fifth of the small intestine. From 4-24 d PI there was no significant difference in recovery with means from 52.3% to 68.0% of the infective inoculum. Worms were congregated in the last two fifths of the intestine at all collection periods. None of the mice that died during the course of the experiment demonstrated unusual behavior prior to death. There was no significant difference in worm load between the 4 animals that died 13-21 d PI and those that were necropsied 16 and 24 d PI (P = 0.435). The results confirm that heavy infections of E. caproni mice can successfully produce large numbers of adult worms; however, outbred ICR mice demonstrate individual differences to these infections that cannot be explained at this time.
机译：在24天的时间内检查了300例ICR小鼠的Caproni棘突感染的过程。七组，每组3只小鼠，感染了300株卡普罗氏大肠杆菌，在感染后24小时（PI），4 d PI，然后以4 d间隔至24 d PI进行了检查。但是，由于尸检前有4只小鼠死亡，因此放弃了20天采集。在检查时，所有小鼠均被蠕虫感染，感染量占初始接种量的13.3％至94.3％。最低的恢复时间是在PI 24小时，平均为26.7％，大多数蠕虫位于小肠的后五分之一。从感染后第4天到第24天，回收率无显着差异，感染菌的平均值为52.3％至68.0％。在所有收集期间，蠕虫都聚集在肠道的后五分之二处。在实验过程中死亡的小鼠均未在死亡前表现出异常行为。 PI死亡13-21 d的4只动物和PI死亡16和24 d尸检的4只动物之间的蠕虫负荷没有显着差异（P = 0.435）。结果证实，重度感染卡普罗尼大肠杆菌的小鼠可以成功产生大量成虫。但是，远距离ICR小鼠表现出与这些感染的个体差异，目前尚无法解释。

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