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首页> 外文期刊>Clinical and experimental obstetrics and gynecology >Impact of Factor V Leiden, prothrombin and methylenetetrahydrofolate reductase gene mutations on infant birth weight in women with recurrent fetal loss and women with successful pregnancies
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Impact of Factor V Leiden, prothrombin and methylenetetrahydrofolate reductase gene mutations on infant birth weight in women with recurrent fetal loss and women with successful pregnancies

机译：因子V莱顿，凝血酶原和亚甲基四氢叶酸还原酶基因突变对反复流产和成功妊娠妇女婴儿出生体重的影响

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Purpose: The aim of this study was to verify whether FV Leiden, PT G20210A, MTHFR C667T or MTHFR A1298C mutations influence the risk of recurrent fetal loss in a sample of Turkish women who had experienced recurrent fetal loss and to evaluate whether the aforementioned thrombophilias and recurrent fetal loss may affect the birth weight of subsequent pregnancies. Methods: Fifty-eight women with recurrent pregnancy loss and 30 women with successful pregnancies were evaluated. Results: The average birth weights for infants of all women in the study group and for infants of thrombophilia-positive women in the study group were markedly lower than the birth weight of infants in the control group (p < 0.001 and p < 0.001, respectively). Conclusion: Successful pregnancies in women with a history of recurrent fetal losses may be associated with lower birth weights compared to controls, irrespective of thrombophilia status. This conclusion warrants further research.
机译：目的：本研究的目的是验证FV Leiden，PT G20210A，MTHFR C667T或MTHFR A1298C突变是否影响复发性胎儿丢失的土耳其妇女样本中复发性胎儿丢失的风险，并评估上述血友病和反复的胎儿流失可能会影响随后怀孕的出生体重。方法：对58名复发性流产妇女和30例成功妊娠妇女进行了评估。结果：研究组中所有妇女的婴儿的平均出生体重和研究组中血栓形成阳性妇女的婴儿的平均出生体重均显着低于对照组的婴儿的出生体重（分别为p <0.001和p <0.001 ）。结论：具有反复胎儿丢失史的女性成功怀孕可能与出生体重较对照组低有关，而与血栓形成状态无关。这一结论值得进一步研究。

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