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首页> 外文期刊>Авиаκосмичесκая и эκологичесκая медицина >Muscle atrophy in microgravity and during its simulation
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Muscle atrophy in microgravity and during its simulation

机译：微重力下的肌肉萎缩及其模拟

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Summarized are the results of comparative analysis of morphological changes in rat's skeletal muscles after microgravity and its simulation. On completion of space flight, hindlimb muscles of rats exhibited atrophy developed in space microgravity in consequence of the lack of weight-bearing loads and changes solely in the slow anti-g muscles due to the hemodynamic disorders appearing after space flight. Immobilization combined with clinostatting cannot be a veridical laboratory model of microgravity, as horizontally positioned animals still possess weight and, besides, experience severe chronic stress of immobilization. Tail suspension with the head-end permanently down and the hind limbs out of use appeared the most demonstrative model of the space microgravity effects. With this model, the hindlimb muscles underwent changes identical to what had been observed in space flown animals. Data of the simulation studies suggest stabilization of muscle atrophy at a certain level and an earlier and stronger reaction to the hindlimb unloading in young rats as compared to old animals. Skeletal muscles in females and males responded to suspension similarly in spite of difference in the hormonal status. environmental medicine.
机译：总结了微重力作用后大鼠骨骼肌形态变化的比较分析结果及其模拟结果。太空飞行完成后，大鼠的后肢肌肉由于缺乏负重负荷而表现出在太空微重力中出现的萎缩，并且由于太空飞行后出现的血液动力学异常，仅缓慢的抗g肌肉发生了变化。固定与斜肌固定相结合不能成为微重力的垂直实验室模型，因为水平放置的动物仍具有体重，而且还会遭受严重的慢性固定压力。尾部悬垂，头端永久垂下，后肢停用，这是空间微重力效应的最典型模型。在这种模型中，后肢肌肉的变化与在太空飞行的动物中观察到的变化相同。模拟研究的数据表明，与老年动物相比，幼鼠对肌肉萎缩的维持在一定水平，并且对后肢卸载的反应更早，更强。尽管荷尔蒙状态有所不同，但雌性和雄性的骨骼肌对悬浮的反应也类似。环境医学。

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