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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Endothelins in health and disease: an overview.
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Endothelins in health and disease: an overview.

机译：内皮素与健康和疾病：概述。

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1. There is an ever increasing volume of evidence implicating endothelin-1 and its isoforms in a range of disease processes. These include asthma, pulmonary and essential systemic hypertension, cardiac failure and uterine dysfunction. 2. However, it is also important to realize that the endothelins play an obligatory role in normal cellular proliferation, repair and tissue development. 3. The present brief review focuses on some of the physiological and pathophysiological mediator roles of the endothelins and provides a sketch of the receptor systems and some of the signal transduction pathways that are now known to operate following receptor activation. 4. Importantly, it is now clear that the endothelins, their receptors and synthesis and degradation pathways offer potentially important therapeutic targets.
机译：1.越来越多的证据表明内皮素-1及其同工型与多种疾病有关。这些包括哮喘，肺和原发性系统性高血压，心力衰竭和子宫功能障碍。 2.然而，认识到内皮素在正常细胞增殖，修复和组织发育中起强制性作用也很重要。 3.本简要综述着眼于内皮素的某些生理和病理生理介质作用，并概述了受体系统以及目前已知在受体激活后起作用的某些信号转导途径。 4.重要的是，现在很清楚，内皮素，它们的受体以及合成和降解途径提供了潜在的重要治疗靶标。

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