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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Acute exposure to a low level of testosterone impairs relaxation in porcine coronary arteries.
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Acute exposure to a low level of testosterone impairs relaxation in porcine coronary arteries.

机译：急性暴露于低水平的睾丸激素会损害猪冠状动脉的松弛。

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1. While the gender bias associated with coronary artery disease has been suggested to be partially accounted for by the protective effects of oestrogens, the role of testosterone remains unclear. The aim of the present study was to determine whether vasorelaxation could be affected by acute administration of testosterone with and without 17 beta-oestradiol. 2. Precontracted porcine coronary artery rings were relaxed with sodium nitroprusside (SNP), levcromakalim, bradykinin (BK) or A23187. At 1 nmol/L, testosterone impaired relaxations to BK and A23187, while the same concentration of 17 beta-oestradiol potentiated levcromakalim- and SNP-induced relaxations. The impairment of relaxation responses by testosterone was reduced in the presence of 17 beta-oestradiol, while the enhancement by 17 beta-oestradiol was decreased by testosterone. 3. We demonstrate that a low level of testosterone can impair agonist-induced relaxation, an effect that is reduced by 17 beta-oestradiol. This further supports evidence indicating a detrimental role for testosterone in coronary artery disease and suggests that circulating levels of testosterone may undermine the beneficial effects of oestrogen in women.
机译：1.尽管雌激素的保护作用已部分解释了与冠状动脉疾病相关的性别偏见，但睾丸激素的作用仍不清楚。本研究的目的是确定在有和没有17β-雌二醇的情况下，急性给药睾丸激素是否会影响血管舒张。 2.将预收缩的猪冠状动脉环用硝普钠（SNP），左旋马卡林，缓激肽（BK）或A23187放松。在1 nmol / L时，睾丸激素会削弱BK和A23187的舒张作用，而相同浓度的17β-雌二醇会增强左旋克马林和SNP引起的舒张作用。在存在17β-雌二醇的情况下，睾丸激素对松弛反应的损害减少了，而在睾丸激素的作用下，由17β-雌二醇引起的松弛反应的增强被降低了。 3.我们证明了低水平的睾丸激素可以损害激动剂诱导的舒张作用，这种作用被17β-雌二醇所降低。这进一步支持了表明睾丸激素在冠状动脉疾病中有害作用的证据，并表明睾丸激素的循环水平可能破坏雌激素对女性的有益作用。

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