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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Endometrial endothelin: regulator of uterine bleeding and endometrial repair.
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Endometrial endothelin: regulator of uterine bleeding and endometrial repair.

机译：子宫内膜内皮素：子宫出血和子宫内膜修复的调节剂。

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1. Endothelin (ET) and its mRNA are present in endometrium. Expression of ET varies across the menstrual cycle, reaching maximal levels in the premenstrual phase, suggesting a paracrine role in endometrial bleeding and/or repair. 2. The major cellular source of ET is the epithelium, although endothelium and decidualized stroma are additional sites of production. Epithelial ET is the ET-1 isoform and this is able to contract rat thoracic aortic rings ex vivo. 3. Endothelin-1 production by cultured endometrial epithelial cells is markedly increased by serum and, to a lesser extent, by transforming growth factor-beta and interleukin-1 alpha, but not by epidermal growth factor, oxytocin, arginine vasopressin, thrombin or angiotensin II, which stimulate ET production in other tissues. 4. Endothelin-1 has mitogenic actions on endometrial stromal cells; it stimulates the uptake of [3H]-thymidine, acting via the AP-1 cis element c-jun. 5. Neutral endopeptidase (NEP), a membrane-bound ectoenzyme that is capable of degrading ET, is localized principally in endometrial stroma and immunoreactivity is maximal in the secretory phase of the cycle. 6. A potential role for ET in regulating endometrial bleeding is suggested by studies on endometrium from two groups of women who were experiencing abnormal uterine bleeding: users of the contraceptive Norplant (Leiras Co., Turku, Finland) and subjects with documented menorrhagia. In both groups, ET-1 immunoreactivity in endometrial epithelium was markedly reduced compared with the normal menstrual cycle and did not vary cyclically, while NEP immunoreactivity, particularly in the epithelium, was increased. Thus, ET may be involved in endometrial bleeding, as a vasoconstrictor before the onset of menstruation when vasoconstriction is intense and, subsequently, when it may be required in the cessation of menstrual bleeding. Furthermore, the mitogenic actions of ET may play a role in endometrial regeneration and remodelling during the menstrual cycle, particularly following menstruation.
机译：1.子宫内膜中存在内皮素（ET）及其mRNA。 ET的表达在整个月经周期变化，在月经前达到最高水平，提示旁分泌在子宫内膜出血和/或修复中的作用。 2. ET的主要细胞来源是上皮，尽管内皮和蜕膜样基质是额外的生产部位。上皮ET是ET-1同种型，其能够离体收缩大鼠胸主动脉环。 3.血清显着增加了培养的子宫内膜上皮细胞产生内皮素-1的水平，在较小程度上，通过转化生长因子-β和白介素-1α的表达，但表皮生长因子，催产素，精氨酸加压素，凝血酶或血管紧张素的增加却不明显II，刺激其他组织中的ET产生。 4.内皮素-1对子宫内膜基质细胞有丝分裂作用;它通过AP-1顺式元素c-jun刺激[3H]-胸苷的摄取。 5.中性内肽酶（NEP）是一种能够降解ET的膜结合型外切酶，主要位于子宫内膜基质内，免疫活性在该周期的分泌期最大。 6.两组子宫异常出血的妇女的子宫内膜研究表明，ET在调节子宫内膜出血方面具有潜在作用：使用避孕药Norplant的使用者（Leiras Co.，图尔库，芬兰）和有月经过多的受试者。在两组中，与正常月经周期相比，子宫内膜上皮中的ET-1免疫反应性显着降低，并且没有周期性变化，而NEP免疫反应性（特别是在上皮中）升高。因此，ET可能会在月经来潮前作为血管收缩剂参与子宫内膜的出血，这是由于血管收缩作用强烈，随后在停止月经出血时可能需要。此外，ET的促有丝分裂作用可能在月经周期特别是月经后的子宫内膜再生和重塑中起作用。

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