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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Neuroanatomical specificity of the circuits controlling sympathetic outflow to different targets.
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Neuroanatomical specificity of the circuits controlling sympathetic outflow to different targets.

机译:控制交感神经流出到不同目标的电路的神经解剖学特异性。

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摘要

1. Despite the emerging framework that central neural pathways controlling the activity of the sympathetic nervous system are capable of producing highly selective responses, the specific neural pathways governing different sympathetic outflows are poorly understood. 2. Anatomical studies suggest that five brain areas, namely the rostral ventrolateral medulla, the rostral ventromedial medulla, the caudal raphe nuclei, the region containing the A5 noradrenergic neurons and the paraventricular hypothalamic nucleus, provide dominant supraspinal innervation of sympathetic preganglionic neurons. 3. The anatomical parcellation of different functions within and among these cell groups is uncertain. However, recent studies using transynaptic retrograde labelling of neural pathways connected to various sympathetic targets suggest that the circuits controlling these different targets may be partially distinct. Similarly, anatomical studies relying on stimulus-evoked expression of immediate early genes, such as c-fos, suggest that different sympathetic responses may be controlled by distinct, neural circuits. 4. Thus, although many similarities exist in the anatomical circuits innervating different sympathetic targets, possibly supporting the orchestration of global sympathetic responses, differences are also discernible.
机译:1.尽管出现了新的框架,即控制交感神经系统活动的中枢神经通路能够产生高度选择性的反应,但对控制不同交感流出的特定神经通路知之甚少。 2.解剖学研究表明,五个大脑区域,即延髓腹侧延髓,延髓腹侧延髓,尾ra核,含有A5降肾上腺素能神经元和丘脑下丘脑旁核的区域,是交感神经节前神经元的主要脊髓上神经支配。 3.这些细胞群内部和之中的不同功能在解剖学上尚不清楚。但是,最近使用跨神经突触逆向标记的神经通路连接到各种交感神经靶标的最新研究表明,控制这些不同靶标的电路可能部分不同。类似地,解剖学研究依赖于刺激的立即早期基因(例如c-fos)的表达,提示不同的交感反应可能受不同的神经回路控制。 4.因此,尽管在支配不同交感神经目标的解剖回路中存在许多相似之处,可能支持对整体交感神经反应的协调,但也可以看出差异。

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