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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Prolongation of the QT interval in primary aldosteronism.
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Prolongation of the QT interval in primary aldosteronism.

机译：原发性醛固酮增多症患者的QT间隔延长。

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SUMMARY 1. Only limited information is available concerning the changes in the electrocardiogram in primary aldosteronism. The aim of the present study was to determine factors influencing the QTc interval in patients with primary aldosteronism. 2. Nineteen patients with primary aldosteronism caused by a Conn's adenoma and 69 patients with essential hypertension, in whom all possible causes of secondary hypertension had been excluded, were included in the present study. Before and 10-20 days after adrenalectomy, blood and electrocardiographic examinations were conducted. 3. Systolic and diastolic blood pressures in primary aldosteronism were found to be comparable to those in essential hypertension. However, the QTc interval was significantly prolonged and serum potassium concentrations were significantly decreased in patients with primary aldosteronism compared with patients with essential hypertension (492.7 +/- 20.3 vs 428.5 +/- 3.1 msec for QTc interval, respectively (P < 0.01); 3.07 +/- 0.12 vs 4.07 +/- 0.05 mEq/L for serum potassium concentrations, respectively (P < 0.01)). The QTc interval was significantly correlated with serum potassium concentrations in primary aldosteronism (P = 0.0011; r = -0.6902), but not in patients with essential hypertension. 4. Blood pressure significantly decreased after adrenalectomy. Furthermore, serum potassium concentrations increased significantly and did not correlate with the QTc interval after adrenalectomy (P = 0.54; r = -0.1500). 5. Our results indicate that the QTc interval is prolonged in patients with primary aldosteronism, probably owing to hypokalaemia.
机译：概述1.关于原发性醛固酮增多症的心电图变化，仅有有限的信息。本研究的目的是确定影响原发性醛固酮增多症患者QTc间隔的因素。 2.本研究包括19例由Conn腺瘤引起的原发性醛固酮增多症患者和69例原发性高血压患者，其中排除了继发性高血压的所有可能原因。肾上腺切除术之前和之后10-20天，进行了血液和心电图检查。 3.发现原发性醛固酮增多症的收缩压和舒张压与原发性高血压相当。然而，与原发性醛固酮增多症患者相比，原发性醛固酮增多症患者的QTc间隔明显延长，而血清钾浓度显着降低（QTc间隔分别为492.7 +/- 20.3和428.5 +/- 3.1 ms（P <0.01）;血清钾浓度分别为3.07 +/- 0.12和4.07 +/- 0.05 mEq / L（P <0.01））。 QTc间隔与原发性醛固酮增多症患者的血钾浓度显着相关（P = 0.0011; r ​​= -0.6902），但与原发性高血压患者无关。 4.肾上腺切除术后血压明显下降。此外，肾上腺切除术后血清钾浓度显着增加且与QTc间隔无关（P = 0.54; r = -0.1500）。 5.我们的结果表明，原发性醛固酮增多症患者的QTc间隔延长，可能是由于低钾血症所致。

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