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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Insulin secretion from beta cells within intact islets: Location matters
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Insulin secretion from beta cells within intact islets: Location matters

机译：完整胰岛内β细胞的胰岛素分泌：位置很重要

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摘要

The control of hormone secretion is central to body homeostasis, and its dysfunction is important in many diseases. The key cellular steps that lead to hormone secretion have been identified, and the stimulus-secretion pathway is understood in outline for many endocrine cells. In the case of insulin secretion from pancreatic beta cells, this pathway involves the uptake of glucose, cell depolarization, calcium entry, and the triggering of the fusion of insulin-containing granules with the cell membrane. The wealth of information on the control of insulin secretion has largely been obtained from isolated single-cell studies. However, physiologically, beta cells exist within the islets of Langerhans, with structural and functional specializations that are not preserved in single-cell cultures. This review focuses on recent work that is revealing distinct aspects of insulin secretion from beta cells within the islet.
机译：激素分泌的控制对于身体稳态是至关重要的，其功能障碍在许多疾病中都很重要。已经确定了导致激素分泌的关键细胞步骤，并且对于许多内分泌细胞，其刺激-分泌途径已被概述。在胰腺β细胞分泌胰岛素的情况下，该途径涉及葡萄糖的摄取，细胞去极化，钙进入以及含胰岛素的颗粒与细胞膜融合的触发。有关胰岛素分泌控制的大量信息已从孤立的单细胞研究中获得。但是，在生理上，β细胞存在于Langerhans的胰岛中，其结构和功能专长在单细胞培养物中无法保留。这篇综述的重点是最近的工作，这些工作揭示了胰岛内β细胞分泌胰岛素的不同方面。

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