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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Relevance of cytochrome P450 levels in the actions of enflurane and isoflurane in mice: studies on the haem pathway.
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Relevance of cytochrome P450 levels in the actions of enflurane and isoflurane in mice: studies on the haem pathway.

机译：细胞色素P450水平与小鼠中环戊烷和异氟烷作用的相关性：血红素途径的研究。

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摘要

1. The effect of the fluorinated ether anaesthetics enflurane and isoflurane in mice on haem metabolism and regulation in different metabolic states, such as depression and induction of cytochrome P450 produced by allylisopropylacetamide (AIA) and imidazole, respectively, was investigated. 2. Mice previously treated with AIA (350 mg/kg, i.p.) or imidazole (400 mg/kg, i.p.) received a single dose (1 mL/kg, i.p.) of enflurane or isoflurane and were killed 20 min after anaesthetic administration. 3. Induction of delta-aminolevulinic acid synthetase (ALA-S) activity was found, as expected, in animals receiving AIA and also in animals treated with AIA plus anaesthesia, but no change in the activity of either porphobilinogenase (PBGase) or porphobilinogen deaminase (PBG-D) activities was detected in these two groups of animals. An additional increase in haem destruction was observed in the AIA plus isoflurane-treated group. When mice were injected with imidazol alone or in combination with the anaesthetics, ALA-S activity was increased 50-90% in all groups, but again no change in PBGase or PBG-D activity was observed. Haem oxygenase was diminished in mice receiving imidazole and anaesthesia. 4. In conclusion, neither enflurane nor isoflurane caused additional disturbances in haem metabolism to those produced by AIA or imidazole alone.
机译：1.研究了氟醚麻醉剂安氟烷和异氟烷对小鼠不同血红素代谢和调节血红素代谢的影响，例如分别抑制和诱导烯丙基异丙基乙酰胺（AIA）和咪唑产生的细胞色素P450。 2.先前用友邦保险（350 mg / kg，腹腔内）或咪唑（400 mg / kg，腹腔内）治疗的小鼠接受单剂量（1 mL / kg，腹腔内）安氟醚或异氟烷，并在麻醉后20分钟杀死。 3.如预期的那样，在接受AIA的动物以及接受AIA加麻醉的动物中发现了δ-氨基乙酰丙酸合成酶（ALA-S）活性的诱导，但是胆色素原酶（PBGase）或胆色素原脱氨酶的活性均未改变在这两组动物中检测到（PBG-D）活动。在友邦保险加异氟烷治疗组中观察到血红素破坏的进一步增加。当给小鼠单独注射咪唑或与麻醉剂一起注射时，所有组的ALA-S活性均提高了50-90％，但再次未观察到PBGase或PBG-D活性的变化。接受咪唑和麻醉的小鼠血红素加氧酶减少。 4.总之，与单独使用友邦保险或咪唑所产生的血红素代谢或异氟烷相比，Enflurane或异氟烷均不会引起血红素代谢的其他紊乱。

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