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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Role for capillaries in coupling blood flow with metabolism.
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Role for capillaries in coupling blood flow with metabolism.

机译：毛细血管在血液流动与新陈代谢耦合中的作用。

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1. Skeletal muscle blood flow is coupled with metabolism; for this coupling to be effective in matching blood flow to capillary exchange, control of capillary blood flow and recruitment must reside at the capillary level. 2. Capillaries are, indeed, capable of sensing and responding to vasoactive stimuli. We report studies that indicate that contraction of skeletal muscle fibres underneath capillaries is capable of increasing blood flow in those capillaries. 3. This presumed metabolically related signal initiates remote dilations in arterioles upstream of the stimulated capillaries. Our findings indicate that the vasodilatory signal is transmitted along the blood vessel wall. 4. Although we present evidence supporting a role for gap junctionally mediated communication of this vasodilatory signal, it appears unlikely to be primarily electrotonic spread of membrane potential changes. 5. Our studies further indicate that the transmitted signal is not dependent on changes in endothelial cell calcium.
机译：1.骨骼肌血流与新陈代谢有关;为了使这种耦合有效地使血液流与毛细管交换相匹配，必须在毛细管水平上控制毛细管血流和募集。 2.毛细血管确实能够感知和响应血管活性刺激。我们报告的研究表明，毛细血管下方骨骼肌纤维的收缩能够增加这些毛细血管中的血流量。 3.这种推测的代谢相关信号在受刺激的毛细血管上游启动了小动脉的远端扩张。我们的发现表明血管舒张信号沿血管壁传输。 4.尽管我们目前提供证据支持间隙连接介导的这种血管舒张信号的传递，但似乎不太可能主要是膜电位变化的电声传播。 5.我们的研究进一步表明，传输的信号不依赖于内皮细胞钙的变化。

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