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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats.
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Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats.

机译：大蒜引起一氧化氮依赖性松弛，并抑制大鼠低氧性肺血管收缩。

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1. The aims of the present study were to determine the characteristics of garlic extract-induced relaxation in rat isolated pulmonary arteries, its susceptibility to changes in oxygen tension and its protective effect against hypoxic pulmonary vasoconstriction. 2. In normoxia, garlic extract (3-500 microg/mL) produced a dose- and nitric oxide (NO)-dependent relaxation. Following 60 min hypoxia, maximum garlic relaxation was reduced compared with control (mean (-SEM) -86 +/- 3 vs-69 +/- 2% of phenylephrine (PE) precontraction, respectively), but recovered after 60 min reoxygenation (-85 +/- 3% PE precontraction). 3. Acetylcholine (0.1 micromol/L)-induced NO-dependent relaxation was reduced from a control value of -76 +/- 1% to -46 +/- 4% during hypoxia and was further reduced to -35 +/- 2 % after reoxygenation. 4. In endothelium-intact arteries, hypoxic exposure resulted in a triphasic response: early transient contraction (+24 +/- 4%), followed by transient relaxation (-37 +/- 7%) and then sustained contraction (+62 +/- 5%). 5. Pretreatment with NG-nitro-L-arginine methyl ester abolished the early transient contraction, moderately attenuated the sustained contraction and had no effect on the transient relaxation. Mechanical endothelial disruption inhibited all hypoxia-induced vascular changes. 6. Garlic pretreatment had no effect on the early transient contraction (+25 +/- 4%), but inhibited the transient relaxation (-5 +/- 3%; P<0.05) and the sustained contraction (+26 +/- 5%; 7. Garlic also significantly inhibited endothelin-l-induced contractions in a dose-dependent manner. 8. These findings show that garlic extract modulates the production and function of both endothelium-derived relaxing and constricting factors and this may contribute to its protective effect against hypoxic pulmonary vasoconstriction.
机译：1.本研究的目的是确定大蒜提取物引起的大鼠离体肺动脉松弛的特征，其对氧张力变化的敏感性以及对缺氧性肺血管收缩的保护作用。 2.在常氧状态下，大蒜提取物（3-500微克/毫升）产生剂量和一氧化氮（NO）依赖性的舒张作用。缺氧60分钟后，与对照相比，大蒜的最大舒张度降低了（均值（-SEM）分别为-86 +/- 3 vs-69 +/- 2％的去氧肾上腺素（PE）预收缩），但在重新充氧60分钟后恢复了（ -85 +/- 3％PE预收缩）。 3.缺氧时乙酰胆碱（0.1 micromol / L）诱导的NO依赖性舒张从控制值-76 +/- 1％降低到-46 +/- 4％，并进一步降低到-35 +/- 2再氧化后的％。 4.在内皮完整的动脉中，低氧暴露导致三相反应：早期短暂收缩（+24 +/- 4％），然后短暂松弛（-37 +/- 7％），然后持续收缩（+62 + /-5％）。 5.用NG-硝基-L-精氨酸甲酯预处理可消除早期瞬时收缩，适度减弱持续收缩，并且对瞬时松弛没有影响。机械性内皮破坏抑制了所有缺氧引起的血管变化。 6.大蒜预处理对早期瞬时收缩没有影响（+25 +/- 4％），但抑制了瞬时松弛（-5 +/- 3％; P <0.05）和持续收缩（+26 +/-） 5％; 7。大蒜还以剂量依赖性方式显着抑制内皮素-1诱导的收缩。8.这些发现表明，大蒜提取物可调节内皮源性舒张和收缩因子的产生和功能，这可能有助于其生长。对缺氧性肺血管收缩的保护作用。

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