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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Cardioprotective effects of nicorandil in rabbits anaesthetized with halothane: potentiation of ischaemic preconditioning via KATP channels.
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Cardioprotective effects of nicorandil in rabbits anaesthetized with halothane: potentiation of ischaemic preconditioning via KATP channels.

机译：尼可地尔对氟烷麻醉的兔的心脏保护作用：通过KATP通道增强缺血预处理。

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1. The roles of ATP-sensitive K+ channels (KATP channels) in ischaemic or pharmacological preconditioning in the rabbit heart remain unclear. Infarct limitation by ischaemic preconditioning was abolished by the KATP channel blocker glibenclamide under ketamine/xylazine anaesthesia, but not under anaesthesia induced by pentobarbital. Infarct limitation by the KATP channel opener pinacidil was detected under ketamine/xylazine anaesthesia, but not under pentobarbital anaesthesia. Thus, these effects appear to be anaesthetic dependent. 2. In the present study, we examined whether nicorandil (a KATP channel opener nitrate) exhibits cardioprotective actions under halothane anaesthesia, another commonly used volatile anaesthetic. Control animals were subjected to 40 min coronary occlusion and 120 min reperfusion. Before 40 min ischaemia, the nicorandil group received nicorandil (100 microg/kg per min, i.v., for 10 min), the 5' preconditioning (PC) group received 5 min ischaemia/20 min reperfusion, the 2.5'PC group received 2.5 min preconditioning ischaemia/20 min reperfusion, the nicorandil +2.5'PC group received both nicorandil and 2.5 min ischaemia/20 min reperfusion, the nicorandil +2.5'PC + 5-hydroxydecanoate (5HD) group received both nicorandil and 2.5 min ischaemia/20 min reperfusion in the presence of 5-hydroxydecanoate (5HD; a KATP blocker) and the 5HD group received 5 mg/kg, i.v., 5HD alone. Myocardial infarct size in control (n = 7), nicorandil (n = 5), 5'PC (n = 8), 2.5'PC (n = 5), nicorandil + 2.5'PC (n = 5), nicorandil + 2.5'PC + 5HD (n = 5) and 5HD (n = 4) groups averaged 44.4 +/- 3.6, 41.7 +/- 5.7, 17.8 +/- 3.2,* 34.1 +/- 4.8, 21.3 +/- 4.2,* 39.1 +/- 5.6 and 38.9 +/- 5.0% of the area at risk, respectively (*P <0.05 vs control). 3. Thus, nicorandil alone did not have an infarct size-limiting effect in halothane-anaesthetized rabbits. However, the results suggest that even when nicorandil alone does not demonstrate a direct cardioprotective effect, it may enhance ischaemic preconditioning via KATP channels. Key words: ATP-sensitive K+ (KATP) channel, ischaemic preconditioning, myocardial infarction, nicorandil, rabbit.
机译：1.尚不清楚ATP敏感性K +通道（KATP通道）在兔心脏缺血或药理预处理中的作用。在氯胺酮/甲苯噻嗪麻醉下，KATP通道阻滞剂格列本脲取消了缺血预处理的梗塞限制，但在戊巴比妥诱导的麻醉下则没有。在氯胺酮/甲苯噻嗪麻醉下可检测到KATP通道开放剂品那地尔的梗塞限制，而在戊巴比妥麻醉下则未检测到。因此，这些作用似乎与麻醉有关。 2.在本研究中，我们检查了尼可地尔（KATP通道开放剂硝酸盐）在氟烷麻醉下是否表现出心脏保护作用，氟烷是另一种常用的挥发性麻醉剂。对照动物经受40分钟的冠状动脉闭塞和120分钟的再灌注。缺血40分钟前，尼古地尔组接受尼可地尔（每分钟100微克/千克，静脉内，持续10分钟），5'预适应（PC）组接受5分钟局部缺血/ 20分钟再灌注，2.5'PC组接受2.5分钟预处理缺血/ 20分钟再灌注，尼可地尔+ 2.5'PC组同时接受尼可地尔和2.5分钟缺血/ 20分钟再灌注，尼可地尔+ 2.5'PC + 5-羟基癸酸酯（5HD）组同时接受尼可地尔和2.5分钟缺血/ 20分钟在5-羟基癸酸酯（5HD;一种KATP阻断剂）存在下进行再灌注，而5HD组仅静脉注射5HD / kg，5 mg / kg。对照的心肌梗死面积（n = 7），尼可地尔（n = 5），5'PC（n = 8），2.5'PC（n = 5），尼可地尔+ 2.5'PC（n = 5），尼可地尔+ 2.5 'PC + 5HD（n = 5）和5HD（n = 4）组的平均值为44.4 +/- 3.6、41.7 +/- 5.7、17.8 +/- 3.2，* 34.1 +/- 4.8、21.3 +/- 4.2，*分别是危险区域的39.1 +/- 5.6和38.9 +/- 5.0％（相对于对照组，* P <0.05）。 3.因此，单独使用尼可地尔对氟烷麻醉的兔子没有梗塞大小限制作用。然而，结果表明，即使单独使用尼可地尔也不能显示出直接的心脏保护作用，它也可以通过KATP通道增强缺血预处理。关键词：ATP敏感性K +（KATP）通道，缺血预处理，心肌梗死，尼可地尔，兔。

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