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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Sucrose-rich feeding during rat pregnancy-lactation and/or after weaning alters glucose and lipid metabolism in adult offspring
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Sucrose-rich feeding during rat pregnancy-lactation and/or after weaning alters glucose and lipid metabolism in adult offspring

机译：大鼠妊娠期和/或断奶后富含蔗糖的喂养会改变成年后代的葡萄糖和脂质代谢

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摘要

Adverse fetal and early life environments predispose to the development of metabolic disorders in adulthood. The present study examined whether offspring of normal Wistar dams fed a high-sucrose diet (SRD) developed impaired lipid and glucose homeostasis when fed a control diet (CD) after weaning. In addition, we investigated whether there were more pronounced derangements in lipid and glucose homeostasis when offspring of SRD-fed Wistar were fed an SRD after weaning compared with those in offspring of CD-fed dams weaned on an SRD. During pregnancy and lactation, female rats were fed either an SRD or CD. After weaning, half the male offspring from both groups were fed a CD or SRD, up to 100 days of age (CD-CD, CD-SRD, SRD-SRD and SRD-CD groups). Final bodyweight was similar between all groups, although offspring of SRD-fed dams had lighter bodyweight at birth. Plasma lipid and glucose levels were significantly higher (P < 0.05) without changes in insulin levels in the CD-SRD, SRD-SRD and SRD-CD groups compared with the CD-CD group. Dyslipidaemia in the CD-SRD and SRD-SRD groups resulted from increased secretion of very low-density lipoprotein triacylglycerol, as well as decreased triacylglycerol (TAG) clearance that was associated with increased liver TAG content (P < 0.05) compared with the CD-CD group. The hypertriglyceridaemia observed in the SRD-CD group was mostly associated with decreased TAG clearance. Altered glucose and insulin tolerance were observed when the SRD was fed during any period of life. These data support the hypothesis that early life exposure to SRD is associated with changes in lipid and glucose metabolism, leading to an unfavourable profile in adulthood, regardless of whether offspring consumed an SRD after weaning.
机译：不利的胎儿和早期生活环境容易导致成年后代谢异常的发展。本研究检查了断奶后喂高糖饮食（SRD）的正常Wistar大坝的后代在喂食对照饮食（CD）后是否出现脂质和葡萄糖体内稳态受损。此外，我们调查了断奶后饲喂SRD饲喂的Wistar的后代与断饲SRD饲喂的CD饲喂的大坝的后代相比，在脂和葡萄糖稳态中是否存在更明显的脂质和葡萄糖稳态紊乱。在怀孕和哺乳期间，给雌性大鼠喂食SRD或CD。断奶后，两组的一半雄性后代均接受CD或SRD喂养，直至100天（CD-CD，CD-SRD，SRD-SRD和SRD-CD组）。尽管SRD喂养的大坝的后代出生时体重较轻，但所有组的最终体重均相似。与CD-CD组相比，CD-SRD，SRD-SRD和SRD-CD组的血浆脂质和葡萄糖水平显着更高（P <0.05），而胰岛素水平没有变化。与CD-SRD和CD-SRD相比，CD-SRD和SRD-SRD组的血脂异常是由于极低密度脂蛋白三酰甘油的分泌增加以及与肝脏TAG含量增加相关的三酰甘油（TAG）清除率降低（P <0.05）。 CD组。在SRD-CD组中观察到的高甘油三酯血症主要与TAG清除率降低有关。在生命的任何时期进食SRD均会观察到葡萄糖和胰岛素耐受性的改变。这些数据支持以下假设：生命早期暴露于SRD与脂质和葡萄糖代谢的变化相关，从而导致成年后的状况不佳，无论后代在断奶后是否食用了SRD。

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