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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Linkage between Twist1 and Bmi1: Molecular mechanism of cancer metastasis/stemness and clinical implications
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Linkage between Twist1 and Bmi1: Molecular mechanism of cancer metastasis/stemness and clinical implications

机译：Twist1和Bmi1之间的联系：癌症转移/干性的分子机制及其临床意义

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1.Cancer metastasis is the major cause of cancer-related death despite significant improvements in multimodal cancer therapy. Epithelial-mesenchymal transition (EMT), a major mechanism of cancer metastasis, is a process that generates cells with stem cell-like properties (cancer stemness). 2.Cancer stemness is a concept that describes a minor population of cells (cancer stem cells) residing within a tumour that are able to self-renew and are resistant to conventional therapy. The mechanisms delineating the generation of cancer stemness and its connection to cancer metastasis remain largely unknown. 3.Twist1 is an EMT regulator and increased Twist1 expression, which has prognostic significance in various human cancers, has been widely reported. Bmi1 is a critical component of polycomb repressive complex (PRC) 1, which maintains self-renewal and stemness. Bmi1 is frequently overexpressed in different types of human cancers and can induce drug resistance (Table 2). 2 Expression and clinical implication of Twist1 and Bmi1 in human cancers: Cancer site Twist1 overexpression Bmi1 overexpression Head and neck squamous cell carcinoma Metastasis Poor overall survival Poor overall survival Breast carcinoma Poor overall survival Poor overall survival Cervical carcinoma Poor overall survival Poor overall survival Gastric cancer Histological type Poor overall survival Hepatocarcinomas Distant metastasis Recurrence Poor overall survival Non-small cell lung cancer Poor overall survival Tumour progression Poor overall survival Colon cancer Tumour progression Poor overall survival Poor overall survival Bladder cancer Poor progression-free survival Poor overall survival Oesophageal squamous cell carcinoma Distant metastasis Poor overall survival Poor overall survival Ovarian cancer Tumour progression Poor overall survival Prostate cancer Metastasis Chronic myeloid leukaemia Disease progression Medulloblastoma Poor overall survival 4.Recent studies have shown that Twist1 directly activates Bmi1 expression and that these two molecules function together to mediate cancer stemness and EMT. These results present a unique mechanism of EMT-induced cancer metastasis and stemness. 5.Further investigation of the mechanisms of EMT-mediated cancer metastasis and stemness will contribute to the management and treatment of metastatic cancers.
机译：1.尽管多模式癌症治疗有了显着改善，但癌症转移仍是癌症相关死亡的主要原因。上皮-间质转化（EMT）是癌症转移的主要机制，是一种产生具有干细胞样特性（癌干性）的细胞的过程。 2癌干性是一个概念，它描述了存在于肿瘤中的少数细胞（癌干细胞），它们能够自我更新并对常规疗法产生抵抗力。描绘癌症干的产生及其与癌症转移的关系的机制在很大程度上仍然未知。 3.Twist1是一种EMT调节剂，Twist1表达的增加在多种人类癌症中具有预后意义。 Bmi1是多梳抑制复合物（PRC）1的重要组成部分，可保持自我更新和干爽。 Bmi1在不同类型的人类癌症中经常过表达，并且可以诱导耐药性（表2）。 2 Twist1和Bmi1在人类癌症中的表达及其临床意义：癌症位点Twist1过表达Bmi1过表达头颈部鳞状细胞癌转移总体生存率差总体生存率差乳腺癌总体生存率差总体生存率差宫颈癌总体生存率差总体生存率差胃癌总体率组织学类型总体生存不良肝癌远处转移复发总体生存不良非小细胞肺癌总体生存不良肿瘤进展总体生存不良结肠癌肿瘤进展总体生存不良总体生存不良膀胱癌不良无进展生存总体生存不良食管鳞状细胞癌远处转移总体生存不良总体生存不良卵巢癌肿瘤进展总体生存不良前列腺癌转移慢性粒细胞白血病疾病进展髓母细胞瘤总体生存不良4.近期研究表明在Twist1处的Bat1直接激活Bmi1表达，并且这两个分子共同起作用以介导癌症干和EMT。这些结果提出了EMT诱导的癌症转移和干性的独特机制。 5.对EMT介导的癌症转移和干性机制的进一步研究将有助于转移性癌症的管理和治疗。

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