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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Role of endothelin-1 receptors in healthy anaesthetized rabbits.
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Role of endothelin-1 receptors in healthy anaesthetized rabbits.

机译：内皮素-1受体在健康麻醉兔子中的作用。

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1. Many diseases are associated with elevated endothelin (ET)-1 plasma concentrations. In order to understand the consequence of this elevation, in the present study the effects of exogenous ET-1 on the entire organsim were investigated, in particular with respect to the role of ETA and ETB receptors in the cardiovascular system. In open-chest rabbits, left ventricular (LV) pressure (LVPmax, LVPed), dP/dtmax and dP/dtmin were recorded in ejecting and isovolumically beating hearts to determine cardiac function. In addition, heart rate (HR), aortic pressure (AoP) and aortic flow (AoF) were measured. Total peripheral resistance (TPR) was calculated from mean AoP and AoF. 2. In the first series of experiments (n = 11), ET-1 (0.5 nmol/kg; bolus) produced a non-significant reduction in HR. Systolic function, in terms of AoF, LVPmax and dP/dtmax, was improved; for example, LVPmax was increased significantly (69 +/- 10 vs 106 +/- 20 mmHg for control and ET-1, respectively; P < 0.05). Similarly, early relaxation (dP/dtmin) was improved. In parallel, TPR rose significantly (0.25+/-0.07 vs 0.35+/-0.1 mmHg/min per mL for control and ET-1, respectively; P < 0.05). Isovolumic measurements showed corresponding responses. 3. In the second series of experiments (n = 7), animals were pretreated with an ETA receptor antagonist (330 nmol/min per kg FR 139317). After ETA receptor blockade, the administration of ET-1 had no significant effect on cardiac function or vasomotion. 4. In the third series of experiments (n = 6), animals were pretreated with an ETB receptor antagonist (10 nmol/min per kg BQ 788). In this series of experiments, the effects of ET-1 on cardiac function and vasomotion were the same as in the first series of experiments, except for the effect on HR, which decreased by 35% after ET-1. 5. In our experimental model, exogenous ET-1 exerted a clear-cut positive inotropic effect, together with the anticipated peripheral vasoconstriction via ETA receptors.
机译：1.许多疾病与内皮素（ET）-1血浆浓度升高有关。为了理解这种升高的后果，在本研究中，研究了外源性ET-1对整个器官的影响，特别是关于ETA和ETB受体在心血管系统中的作用。在开胸的兔子中，在跳动和等容跳动的心脏中记录左心室（LV）压力（LVPmax，LVPed），dP / dtmax和dP / dtmin，以确定心脏功能。此外，还测量了心率（HR），主动脉压（AoP）和主动脉血流（AoF）。由平均AoP和AoF计算总外周电阻（TPR）。 2.在第一个系列实验（n = 11）中，ET-1（0.5 nmol / kg;推注）导致HR无明显降低。在AoF，LVPmax和dP / dtmax方面的收缩功能得到改善;例如，LVPmax显着增加（对照组和ET-1分别为69 +/- 10和106 +/- 20 mmHg; P <0.05）。同样，早期放松（dP / dtmin）也得到了改善。同时，TPR显着上升（对照和ET-1分别为0.25 +/- 0.07和0.35 +/- 0.1 mmHg / min / mL; P <0.05）。等容测量显示相应的响应。 3.在第二系列实验（n = 7）中，动物用ETA受体拮抗剂（330 nmol / min / kg FR 139317）进行预处理。 ETA受体阻滞后，ET-1的使用对心功能或血管舒张没有明显影响。 4.在第三组实验（n = 6）中，将动物用ETB受体拮抗剂（每千克BQ 788 10 nmol / min）进行预处理。在这一系列实验中，除了对HR的影响（在ET-1之后降低了35％）之外，ET-1对心功能和血管舒张的影响与第一系列实验相同。 5.在我们的实验模型中，外源性ET-1发挥了明确的正性肌力作用，并预期通过ETA受体引起外周血管收缩。

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