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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Role of nitric oxide synthase inhibitor in experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats.
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Role of nitric oxide synthase inhibitor in experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats.

机译：一氧化氮合酶抑制剂在大鼠2,4,6-三硝基苯磺酸诱导的实验性结肠炎中的作用。

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1. The present study was designed to investigate the role of nitric oxide (NO) in modulating 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis in rats. 2. Damage scores and NO synthase (NOS) activity were measured. 3. The damage scores and NOS activity reached a peak on the 4th day after administration of TNBS solution (day 0), thereafter gradually decreasing, and were significantly higher than in the group treated with saline throughout the experimental period. 4. Subsequently, we divided the stage of colitis into two groups, one from day 0 to day 3 after induction of colitis, and the other from day 4 onwards. We evaluated the effects of the NOS inhibitor N(G)-monomethyl-L-arginine (L-NMMA), on TNBS-hapten-induced colitis and colonic mucosal blood flow. Two different methods of L-NMMA administration, from day 0 to day 3, and from day 4 onwards, were undertaken. 5. The damage score in the early L-NMMA treatment group was significantly higher than in the group without L-NMMA on day 14. In contrast, the damage score in the late L-NMMA treatment group was not significantly different from the group without L-NMMA. Colonic mucosal blood flow in the early L-NMMA treatment group was not significantly different from that in the late L-NMMA treatment group. 6. These data suggest that NO is important for inhibiting inflammation during the early stages.
机译：1.本研究旨在研究一氧化氮（NO）在调节2,4,6-三硝基苯磺酸（TNBS）诱导的大鼠结肠炎中的作用。 2.测量损伤评分和NO合酶（NOS）活性。 3.损伤分数和NOS活性在TNBS溶液给药后第4天（第0天）达到峰值，此后逐渐降低，并且在整个实验期间均明显高于生理盐水治疗组。 4.随后，我们将结肠炎的阶段分为两组，一组从诱导结肠炎后的第0天到第3天，另一组从第4天开始。我们评估了NOS抑制剂N（G）-单甲基-L-精氨酸（L-NMMA）对TNBS半抗原诱导的结肠炎和结肠粘膜血流的影响。从第0天到第3天，以及从第4天开始，采用了两种不同的L-NMMA施用方法。 5.早期L-NMMA治疗组的损伤评分显着高于第14天不使用L-NMMA的组。相比之下，晚期L-NMMA治疗组的损伤评分与未使用L-NMMA的组无明显差异。 L-NMMA。 L-NMMA早期治疗组的结肠黏膜血流量与L-NMMA晚期治疗组的结肠黏膜血流量无明显差异。 6.这些数据表明，NO对于早期抑制炎症很重要。

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